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However, the association of accelerated biological aging relative to chronological age with ADRD pathology is unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>In a cohort of 2366 (873 with longitudinal data) cognitively unimpaired older women, we examined associations of seven baseline measures of epigenetic age acceleration (EAA) and pace of aging with 15\u2010year changes in plasma ADRD biomarkers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>At baseline, higher AgeAccelHorvath and AgeAccelPheno were associated with lower amyloid beta (A\u03b2) 42 to A\u03b240 (A\u03b242:A\u03b240) ratio, and higher AgeAccelGrim2, PCPhenoAge, and PCGrimAge were associated with elevated neurofilament light (NfL). Longitudinally, higher baseline DunedinPACE \u2013 capturing the pace of biological aging \u2013 was associated with faster increases in tau phosphorylated at threonine 181 (p\u2010tau181), p\u2010tau217, NfL, and glial fibrillary acidic protein (GFAP) over 15 years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Accelerated biological aging, particularly DunedinPACE, was associated with increasing levels of plasma ADRD biomarkers over time.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>We studied 2366 older women from the Women's Health Initiative Memory Study.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>AgeAccelHorvath and AgeAccelPheno were linked to lower plasma A\u03b242:A\u03b240 at baseline.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>AgeAccelGrim2, PCPhenoAge, and PCGrimAge were linked to higher plasma NfL at baseline.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>DunedinPACE was associated with faster increases in p\u2010tau181, p\u2010tau217, NfL, and GFAP.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  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