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Lactate is an alternative brain fuel; however, whole\u2010body lactate metabolism has not been measured in AD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>The Lactate for Energy and Neurocognition Trial (NCT05207397) was a single\u2010arm trial that enrolled 24 cognitively healthy (CH) older adults and 12 cognitively impaired (CI) participants. Subjects underwent a stable isotope lactate infusion to evaluate lactate metabolism, cognitive testing, and blood biomarker analyses. pTau217, brain\u2010derived tau (BD\u2010tau), pTau181, glial fibrillary acidic protein (GFAP), neurofilament light chain (NfL), total tau, and brain\u2010derived neurotrophic factor (BDNF) were analyzed by Simoa HD\u2010X (Quanterix).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Lactate metabolic clearance rate did not differ between CH and CI subjects (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.988). After infusion, global cognition was improved (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001) and plasma pTau217 (\u221233.8%,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001), BD\u2010tau (\u221232.6%,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001), pTau181 (\u221221.4%,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001), GFAP (\u221239.7%,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001), and NfL (\u221219.5%,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001) were reduced.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>Lactate turnover was not different between diagnosis groups. Lactate infusion improved cognition and reduced AD fluid biomarkers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Individuals with Alzheimer's disease (AD) can metabolize lactate as well as healthy controls.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Lactate infusion might improve global cognition and processing speed.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Lactate infusion results in significant decrease of AD fluid biomarkers.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.70984","type":"journal-article","created":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T06:06:13Z","timestamp":1765433173000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Acute effects of lactate infusion on metabolism, AD biomarkers, and cognition: The LEAN study"],"prefix":"10.1002","volume":"21","author":[{"given":"Riley E.","family":"Kemna","sequence":"first","affiliation":[{"name":"University of Kansas Alzheimer's Disease Research Center  Fairway Kansas USA"},{"name":"Department of Neurology University of Kansas Medical Center  Kansas City Kansas USA"},{"name":"Department of Cell Biology and Physiology University of Kansas Medical Center  Kansas City Kansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul J.","family":"Kueck","sequence":"additional","affiliation":[{"name":"University of Kansas Alzheimer's Disease Research Center  Fairway Kansas USA"},{"name":"Department of Neurology University of Kansas Medical Center  Kansas City Kansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anneka","family":"Blankenship","sequence":"additional","affiliation":[{"name":"University of Kansas Alzheimer's Disease Research Center  Fairway Kansas USA"},{"name":"Department of Neurology University of Kansas Medical Center  Kansas City Kansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Casey S.","family":"John","sequence":"additional","affiliation":[{"name":"University of Kansas Alzheimer's Disease Research Center  Fairway Kansas USA"},{"name":"Department of Neurology University of Kansas Medical Center  Kansas City Kansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chelsea N.","family":"Johnson","sequence":"additional","affiliation":[{"name":"University of Kansas Alzheimer's Disease Research Center  Fairway Kansas USA"},{"name":"Department of Neurology University of Kansas Medical Center  Kansas City Kansas USA"},{"name":"Department of Cell Biology and Physiology University of Kansas Medical Center  Kansas City Kansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zachary D.","family":"Green","sequence":"additional","affiliation":[{"name":"University of Kansas Alzheimer's Disease Research Center  Fairway Kansas USA"},{"name":"Department of Neurology University of Kansas Medical Center  Kansas City Kansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hana","family":"Mayfield","sequence":"additional","affiliation":[{"name":"University of Kansas Alzheimer's Disease Research Center  Fairway Kansas USA"},{"name":"Department of Neurology University of Kansas Medical Center  Kansas City Kansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Yoksh","sequence":"additional","affiliation":[{"name":"Department of Biostatistics &amp; 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