{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T01:17:05Z","timestamp":1792891025802,"version":"4.5.0"},"reference-count":61,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T00:00:00Z","timestamp":1765411200000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007921","name":"University of Pittsburgh","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007921","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp; Dementia"],"published-print":{"date-parts":[[2025,12]]},"abstract":"Abstract<\/jats:title>\n \n INTRODUCTION<\/jats:title>\n We evaluated plasma biomarker association with, and classification accuracies for, amyloid beta\u2013positron emission tomography (A\u03b2\u2010PET) and cortical thickness in the biracial Human Connectome Project\u2013Connectomics in Brain Aging (HCP\u2010CoBRA) cohort (53% Black\/African American [B\/AA] and 47% non\u2010Hispanic White [NHW]).<\/jats:p>\n <\/jats:sec>\n \n METHODS<\/jats:title>\n \n In\n n<\/jats:italic>\n \u00a0=\u00a0218 participants (median age 62, range: 57\u201371] years, 65% female and 15% A\u03b2\u2010PET positive), plasma biomarkers (phosphorylated tau\u2010181 [p\u2010tau181], p\u2010tau217, p\u2010tau231, glial fibrillary acidic protein [GFAP], neurofilament light chain [NfL], and A\u03b242\/A\u03b240) were compared to A\u03b2\u2010PET and magnetic resonance imaging (MRI) neuroimaging indicators.\n <\/jats:p>\n <\/jats:sec>\n \n RESULTS<\/jats:title>\n \n Plasma p\u2010tau217 (Johnson & Johnson and ALZpath [areas under the curve [AUCs]\u00a0=\u00a00.915\u00a0vs. 0.919]) had high sensitivity and specificity (>85%) for A\u03b2\u2010PET status. All plasma biomarkers except p\u2010tau231 effectively ruled out A\u03b2 pathology (negative predictive value [NPV]\u00a0>95%) but only Johnson & Johnson p\u2010tau217+ was good for confirmation (covariate\u2010adjusted positive predictive value [PPV]\u00a0=\u00a00.909). The plasma biomarkers performed poorly for identifying cortical thickness status but were elevated according to joint A\u03b2\u2010PET and neurodegeneration profiles. Plasma biomarker accuracies for A\u03b2\u2010PET positivity were unaffected by self\u2010identified race, except for ALZpath p\u2010tau217 (\n p<\/jats:italic>\n \u00a0=\u00a00.024). However, correlations with A\u03b2\u2010PET standardized uptake value ratio varied by self\u2010identified race.\n <\/jats:p>\n <\/jats:sec>\n \n DISCUSSION<\/jats:title>\n Plasma p\u2010tau217 is a promising tool for Alzheimer's disease\u2013associated A\u03b2 pathology in older\/middle\u2010aged individuals. However, apparent race\u2010related performances should be further studied.<\/jats:p>\n <\/jats:sec>\n \n Highlights<\/jats:title>\n \n \n \n Plasma phosphorylated tau\u2010217 (p\u2010tau217) and glial fibrillary acidic protein (GFAP) best predicted abnormal brain amyloid beta\u2013positron emission tomography (A\u03b2\u2010PET).<\/jats:p>\n <\/jats:list-item>\n \n \n Plasma p\u2010tau217 accurately identified abnormal A\u03b2\u2010PET (Johnson & Johnson p\u2010tau217: area under the curve [AUC]\u00a0=\u00a00.9145, 95% confidence interval [CI]\u00a0=\u00a00.8367\u20130.9923; ALZpath\n p<\/jats:italic>\n \u2010tau217: AUC\u00a0=\u00a00.9198, 95% CI\u00a0=\u00a00.8585\u20130.981) followed by GFAP and A\u03b242\/40 ratio (GFAP: AUC\u00a0=\u00a00.8529, 95% CI\u00a0=\u00a00.7485\u20130.9573; A\u03b242\/40:AUC\u00a0=\u00a00.7962, 95% CI\u00a0=\u00a00.6581\u20130.9346).\n <\/jats:p>\n <\/jats:list-item>\n \n All plasma biomarkers performed poorly in identifying cortical thickness, despite being higher according to combined A\u03b2\u2010PET and neurodegeneration profiles.<\/jats:p>\n <\/jats:list-item>\n \n \n Correlations of p\u2010tau217 (Johnson & Johnson\n p<\/jats:italic>\n \u00a0<\u00a00.001), p\u2010tau181 (\n p<\/jats:italic>\n \u00a0=\u00a00.005), and A\u03b242\/40\u00a0(\n p<\/jats:italic>\n \u00a0=\u00a00.004) with A\u03b2\u2010PET in predicting amyloid burden were stronger in self\u2010identified non\u2010Hispanic Whites vs Black\/African Americans.\n <\/jats:p>\n <\/jats:list-item>\n \n \n Biomarker accuracies for A\u03b2\u2010PET positivity were unaffected by self\u2010identified race, except ALZpath p\u2010tau217 (\n p<\/jats:italic>\n \u00a0=\u00a00.024).\n <\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/alz.70985","type":"journal-article","created":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T07:07:02Z","timestamp":1765523222000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Plasma biomarkers, brain amyloid\u2010beta pathology, and cortical thickness in a non\u2010Hispanic White and Black\/African American middle\u2010aged community cohort: The HCP\u2010CoBRA study"],"prefix":"10.1002","volume":"21","author":[{"given":"Shayna T.","family":"Brodman","sequence":"first","affiliation":[{"name":"Department of Psychiatry School of Medicine University of Pittsburgh Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Heaton","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Health Data Science School of Public Health University of Pittsburgh Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gallen","family":"Triana\u2010Baltzer","sequence":"additional","affiliation":[{"name":"Neuroscience Biomarkers Johnson & Johnson La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuemei","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Psychiatry School of Medicine University of Pittsburgh Pittsburgh Pennsylvania USA"},{"name":"Alzheimer's Disease Research Center University of Pittsburgh Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Gogola","sequence":"additional","affiliation":[{"name":"Alzheimer's Disease Research Center University of Pittsburgh Pittsburgh Pennsylvania USA"},{"name":"Department of Radiology School of Medicine University of Pittsburgh Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Ilyas","family":"Kamboh","sequence":"additional","affiliation":[{"name":"Alzheimer's Disease Research Center University of Pittsburgh Pittsburgh Pennsylvania USA"},{"name":"Department of Human Genetics School of Public Health University of Pittsburgh Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor L.","family":"Villemagne","sequence":"additional","affiliation":[{"name":"Department of Psychiatry School of Medicine University of Pittsburgh Pittsburgh Pennsylvania USA"},{"name":"Alzheimer's Disease Research Center University of Pittsburgh Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar L.","family":"Lopez","sequence":"additional","affiliation":[{"name":"Alzheimer's Disease Research Center University of Pittsburgh Pittsburgh Pennsylvania USA"},{"name":"Department of Neurology School of Medicine University of Pittsburgh Pittsburgh Pennsylvania 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