{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T20:28:10Z","timestamp":1792096090926,"version":"4.4.0"},"reference-count":60,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T00:00:00Z","timestamp":1764115200000},"content-version":"vor","delay-in-days":25,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>Following regulatory approval of anti\u2010amyloid beta (A\u03b2) therapies, a better characterization of patients receiving these treatments is needed to guide clinical management and inclusion in future trials. This Alzheimer's Association\u2010convened workgroup proposes a terminology, treatment\u2010related amyloid clearance (TRAC), to reflect alterations in disease pathophysiology based on biomarker evidence for clearance of A\u03b2 deposits. TRAC designates biomarker\u2010defined\u00a0pharmacodynamic changes, rather than direct neuropathological evidence, and applies to individuals with (1) pretreatment biomarker confirmation of cerebral A\u03b2 deposition, (2) treatment with an A\u03b2\u2010targeting therapy, and (3) a follow\u2010up biomarker test indicative of partial or full clearance of A\u03b2 deposits. The workgroup currently recommends defining TRAC using amyloid\u2010positron emission tomography (PET) and emphasizes the role of quantitative measurements for defining the degree of clearance. This framework is expected to be adapted over time in response to rapidly evolving biomarker and clinical advances and with the accumulation of real\u2010world data on patients receiving anti\u2010A\u03b2 therapies.<\/jats:p>\n                    <jats:sec>\n                      <jats:title>Highlights<\/jats:title>\n                      <jats:p>\n                        <jats:list list-type=\"bullet\">\n                          <jats:list-item>\n                            <jats:p>TRAC identifies patients with biomarker evidence for clearance of amyloid deposits.<\/jats:p>\n                          <\/jats:list-item>\n                          <jats:list-item>\n                            <jats:p>TRAC is currently defined using amyloid\u2010PET.<\/jats:p>\n                          <\/jats:list-item>\n                          <jats:list-item>\n                            <jats:p>Full TRAC means that PET levels dropped below predetermined positivity threshold.<\/jats:p>\n                          <\/jats:list-item>\n                          <jats:list-item>\n                            <jats:p>Partial TRAC means that PET levels dropped significantly but remain above threshold.<\/jats:p>\n                          <\/jats:list-item>\n                          <jats:list-item>\n                            <jats:p>This framework is meant to guide future research on patients receiving treatment.<\/jats:p>\n                          <\/jats:list-item>\n                        <\/jats:list>\n                      <\/jats:p>\n                    <\/jats:sec>\n                  <\/jats:sec>","DOI":"10.1002\/alz.70997","type":"journal-article","created":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T03:05:54Z","timestamp":1764212754000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Treatment\u2010related amyloid clearance (TRAC): a framework to characterize patients in the era of anti\u2010amyloid therapies"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2581-8100","authenticated-orcid":false,"given":"Renaud","family":"La Joie","sequence":"first","affiliation":[{"name":"Edward and Pearl Fein Memory and Aging Center UCSF Weill Institute for Neurosciences Department of Neurology University of California  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey L.","family":"Cummings","sequence":"additional","affiliation":[{"name":"Chambers\u2010Grundy Center for Transformative Neuroscience Department of Brain Health School of Integrated Health Sciences Kirk Kerkorian School of Medicine University of Nevada  Las Vegas Nevada USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey L.","family":"Dage","sequence":"additional","affiliation":[{"name":"Department of Neurology Indiana University School of Medicine  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas","family":"Galasko","sequence":"additional","affiliation":[{"name":"Department of Neurosciences and Shiley\u2010Marcos Alzheimer's Disease Research Center University of California  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milos D.","family":"Ikonomovic","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Pittsburgh School of Medicine  Pittsburgh Pennsylvania USA"},{"name":"Geriatric Research Education and Clinical Center VA Pittsburgh Healthcare System  Pittsburgh Pennsylvania USA"},{"name":"Department of Psychiatry University of Pittsburgh School of Medicine  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas K.","family":"Karikari","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Pittsburgh School of Medicine  Pittsburgh Pennsylvania 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Martinos Center for Biomedical Imaging Department of Radiology Massachusetts General Hospital, Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shannon L.","family":"Risacher","sequence":"additional","affiliation":[{"name":"Section of Gerontology and Geriatric Medicine Department of Internal Medicine Wake Forest University School of Medicine Winston\u2010Salem North Carolina USA"},{"name":"Center for Neuroimaging Department of Radiology and Imaging Sciences Indiana Alzheimer's Disease Research Center Indiana University School of Medicine  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruben","family":"Smith","sequence":"additional","affiliation":[{"name":"Clinical Memory Research Unit Department of Clinical Sciences Malm\u00f6 Faculty of Medicine Lund University  Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher H.","family":"van 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