{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T17:19:22Z","timestamp":1789147162536,"version":"build-2803163510"},"reference-count":51,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T00:00:00Z","timestamp":1769040000000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["5R37AG015473"],"award-info":[{"award-number":["5R37AG015473"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AG067501"],"award-info":[{"award-number":["R01AG067501"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Epigenetic clocks associate with neuropathology and Alzheimer's disease (AD) clinical risk, but findings are mixed regarding whether clocks associate with blood\u2010based biomarkers and in non\u2010European populations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      We calculated biological age and age acceleration from blood methylation data in 704 older Hispanic adults and tested associations with clinical diagnosis and\n                      <jats:italic>antemortem<\/jats:italic>\n                      biomarker levels.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Age acceleration was significantly associated with sex, clinical diagnosis, and levels of eight plasma biomarkers, including P\u2010tau217 levels. Additionally, biomarker associations trended more significantly among\n                      <jats:italic>APOE<\/jats:italic>\n                      \u2010\u03b54 non\u2010carriers. We also identified that methylation levels in CD4 and CD8 T\u2010cell types are associated with age acceleration.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>We demonstrated that biological age acceleration, measured in blood, in a Hispanic cohort enriched for preclinical individuals, can stratify clinical AD risk and is associated with plasma AD biomarker levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list>\n                        <jats:list-item>\n                          <jats:p>Blood\u2010based aging clocks associate with Alzheimer's disease plasma biomarker levels.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>\n                            Biological aging appears relevant to pathological aging in apolipoprotein E (\n                            <jats:italic>APOE)<\/jats:italic>\n                            \u2010\u03b54 non\u2010carriers.\n                          <\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Immune T\u2010cell composition relates to biological aging.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71005","type":"journal-article","created":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T06:34:52Z","timestamp":1769150092000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Biological age acceleration associates with Alzheimer's disease plasma biomarker levels"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6439-3999","authenticated-orcid":false,"given":"Jaclyn M.","family":"Eissman","sequence":"first","affiliation":[{"name":"The Taub Institute for Research on Alzheimer's Disease and the Aging Brain Columbia University New York New York USA"},{"name":"Gertrude H. Sergievsky Center Columbia University  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiyi","family":"Ma","sequence":"additional","affiliation":[{"name":"The Taub Institute for Research on Alzheimer's Disease and the Aging Brain Columbia University New York New York USA"},{"name":"Gertrude H. Sergievsky Center Columbia University  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Qiao","sequence":"additional","affiliation":[{"name":"The Taub Institute for Research on Alzheimer's Disease and the Aging Brain Columbia University New York New York USA"},{"name":"Gertrude H. Sergievsky Center Columbia University  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dolly","family":"Reyes\u2010Dumeyer","sequence":"additional","affiliation":[{"name":"The Taub Institute for Research on Alzheimer's Disease and the Aging Brain Columbia University New York New York USA"},{"name":"Gertrude H. Sergievsky Center Columbia University  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angel","family":"Piriz","sequence":"additional","affiliation":[{"name":"The Taub Institute for Research on Alzheimer's Disease and the Aging Brain Columbia University New York New York USA"},{"name":"Gertrude H. Sergievsky Center Columbia University  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annie J.","family":"Lee","sequence":"additional","affiliation":[{"name":"The Taub Institute for Research on Alzheimer's Disease and the Aging Brain Columbia University New York New York USA"},{"name":"Gertrude H. Sergievsky Center Columbia University  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael A.","family":"Lantigua","sequence":"additional","affiliation":[{"name":"Vagelos College of Physicians and Surgeons Columbia University  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Medrano","sequence":"additional","affiliation":[{"name":"Pontificia Universidad Cat\u00f3lica Madre y Maestra  Santiago Rep\u00fablica Dominicana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diones Rivera","family":"Mejia","sequence":"additional","affiliation":[{"name":"CEDIMAT Santo Domingo Rep\u00fablica Dominicana"},{"name":"Universidad Nacional Pedro Henriquez Ure\u00f1a  Santo Domingo Rep\u00fablica Dominicana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence S.","family":"Honig","sequence":"additional","affiliation":[{"name":"The Taub Institute for Research on Alzheimer's Disease and the Aging Brain Columbia University New York New York USA"},{"name":"Gertrude H. Sergievsky Center Columbia University  New York New York USA"},{"name":"Vagelos College of Physicians and Surgeons Columbia University  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francine","family":"Grodstein","sequence":"additional","affiliation":[{"name":"Rush Alzheimer's Disease Center Rush University Medical Center  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Bennett","sequence":"additional","affiliation":[{"name":"Rush Alzheimer's Disease Center Rush University Medical Center  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip L.","family":"De Jager","sequence":"additional","affiliation":[{"name":"The Taub Institute for Research on Alzheimer's Disease and the Aging Brain Columbia University New York New York USA"},{"name":"Center for Translational &amp; Computational Neuroimmunology Columbia University  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clifton L.","family":"Dalgard","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Physiology &amp; Genetics Uniformed Services University of the Health Sciences  Bethesda Maryland USA"},{"name":"The American Genome Center, Center for Military Precision Health Uniformed Services University of the Health Sciences  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Mayeux","sequence":"additional","affiliation":[{"name":"The Taub Institute for Research on Alzheimer's Disease and the Aging Brain Columbia University New York New York USA"},{"name":"Gertrude H. 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