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Linear regressions were used to examine cross\u2010sectional associations between AD\/ADRD blood\u2010based biomarkers (BBMs) and baseline depressive symptoms. Interactions between sex or apolipoprotein E (\n                      <jats:italic>APOE<\/jats:italic>\n                      ) \u03b54 carrier status and BBMs were examined.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Higher glial fibrillary acidic protein (GFAP) was associated with higher depressive symptoms. We did not observe an association between amyloid beta 42\/40 ratio, phosphorylated tau181, or neurofilament light chain with depressive symptoms; interactions between sex or\n                      <jats:italic>APOE<\/jats:italic>\n                      \u03b54 with depressive symptoms were not significant.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>In this large, community\u2010based cohort of older adults, plasma GFAP was associated with greater depressive symptoms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Plasma glial fibrillary acidic protein was associated with depressive symptoms.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Neuroinflammation may underlie depressive symptoms in this group.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Future research is needed to examine sex differences in this association.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71007","type":"journal-article","created":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T03:43:48Z","timestamp":1767239028000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The association of Alzheimer's disease and related dementias blood\u2010based biomarkers with depressive symptoms"],"prefix":"10.1002","volume":"22","author":[{"given":"Julia 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University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robyn L.","family":"Woods","sequence":"additional","affiliation":[{"name":"School of Public Health and Preventive Medicine Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Berk","sequence":"additional","affiliation":[{"name":"The Institute for Mental and Physical Health and Clinical Translation (IMPACT), School of Medicine Deakin University  Geelong Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7177-1185","authenticated-orcid":false,"given":"Michelle M.","family":"Mielke","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Prevention Wake Forest University School of Medicine  Winston\u2010Salem North Carolina 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