{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T16:10:44Z","timestamp":1790871044069,"version":"4.1.0"},"reference-count":160,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T00:00:00Z","timestamp":1765584000000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      Oral dysbiosis contributes to Alzheimer's disease (AD) by promoting neuroinflammation. Pathobionts such as\n                      <jats:italic>Porphyromonas gingivalis<\/jats:italic>\n                      ,\n                      <jats:italic>Treponema denticola<\/jats:italic>\n                      , and\n                      <jats:italic>Fusobacterium nucleatum<\/jats:italic>\n                      release virulence factors that induce amyloid beta aggregation and tau hyperphosphorylation, while the loss of commensals like\n                      <jats:italic>Streptococcus salivarius<\/jats:italic>\n                      and\n                      <jats:italic>Neisseria spp<\/jats:italic>\n                      . impairs anti\u2010inflammatory protection, worsening neuronal damage.\n                      <jats:italic>P. gingivalis<\/jats:italic>\n                      is strongly linked to an increased risk of AD, especially in individuals with systemic conditions like diabetes, hypertension, and chronic kidney disease. Its presence in brain tissue correlates with a higher likelihood of AD, while salivary\n                      <jats:italic>Veillonella<\/jats:italic>\n                      and periodontal pathogens in gingival crevicular fluid show potential as non\u2010invasive biomarkers for early AD detection. Therapeutic strategies targeting the oral microbiota, such as gingipain inhibitors, antimicrobials, probiotics, and prebiotics, show promise for mitigating AD risk. However, causal mechanisms and clinical efficacy remain to be fully established. Maintaining microbial balance through preventive and targeted modulation represents an innovative approach to reducing AD susceptibility.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>\n                            We identified\n                            <jats:italic>Porphyromonas gingivalis<\/jats:italic>\n                            ,\n                            <jats:italic>Treponema denticola<\/jats:italic>\n                            , and\n                            <jats:italic>Fusobacterium nucleatum<\/jats:italic>\n                            as key oral pathogens driving Alzheimer's disease (AD) via gingipain\u2010induced amyloid beta aggregation, systemic inflammation, and blood\u2013brain barrier disruption.\n                          <\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Our study revealed diabetes, hypertension, and chronic kidney disease (CKD) amplify AD risk through shared oral dysbiosis, with uremic toxins (CKD) and hyperglycemia (diabetes) exacerbating neuroinflammation.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>\n                            We propose\n                            <jats:italic>Veillonella<\/jats:italic>\n                            in saliva and\n                            <jats:italic>Porphyromonas gingivalis<\/jats:italic>\n                            in gingival crevicular fluid as non\u2010invasive AD biomarkers, correlating with 6 to 10\u00d7 higher AD risk when detected in brain tissue.\n                          <\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Gingipain inhibitors (e.g., COR388), nitrate\u2010reducing probiotics, and integrated dental\u2010neurology care are promising interventions to disrupt the oral\u2013brain axis.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>We advocate for oral microbiome screening in high\u2010risk populations (apolipoprotein E \u03b54 carriers, diabetics) and interdisciplinary approaches to AD prevention.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71011","type":"journal-article","created":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T09:50:40Z","timestamp":1765619440000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Unraveling the oral microbiome's role in Alzheimer's disease: From pathophysiology to therapeutic potential"],"prefix":"10.1002","volume":"21","author":[{"given":"Gilliana","family":"Rozenblum","sequence":"first","affiliation":[{"name":"College of Dental Medicine Lincoln Memorial University  Knoxville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karima","family":"Ait\u2010Aissa","sequence":"additional","affiliation":[{"name":"College of Dental Medicine Lincoln Memorial University  Knoxville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gadeer","family":"Zahran","sequence":"additional","affiliation":[{"name":"College of Dental Medicine Lincoln Memorial University  Knoxville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahdieh","family":"Alipour","sequence":"additional","affiliation":[{"name":"College of Dental Medicine Lincoln Memorial University  Knoxville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amal M.","family":"Sahyoun","sequence":"additional","affiliation":[{"name":"College of Dental Medicine Lincoln Memorial University  Knoxville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Undral","family":"Munkhsaikhan","sequence":"additional","affiliation":[{"name":"College of Dental Medicine Lincoln Memorial University  Knoxville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Kassan","sequence":"additional","affiliation":[{"name":"School of Pharmacy West Coast University  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tauheed","family":"Ishrat","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Neurobiology University of Tennessee Health Science Center  Memphis Tennessee USA"},{"name":"Department of Pharmaceutical Sciences College of Pharmacy The University of Tennessee Health Science Center  Memphis Tennessee USA"},{"name":"Neuroscience Institute University of Tennessee Health Science Center  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Dental Medicine Lincoln Memorial University  Knoxville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ammaar H.","family":"Abidi","sequence":"additional","affiliation":[{"name":"College of Dental Medicine Lincoln Memorial University  Knoxville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Modar","family":"Kassan","sequence":"additional","affiliation":[{"name":"College of Dental Medicine Lincoln Memorial University  Knoxville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,13]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)01124-1"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-220720"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms12091797"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu13030886"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2025.1517154"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro.2016.178"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ibneur.2024.12.004"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S255309"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.20-0104"},{"key":"e_1_2_10_11_1","first-page":"108","article-title":"Association of periodontitis with mild cognitive impairment in older adults","volume":"13","author":"Igase M","year":"2024","journal-title":"JAR Life"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-023-02747-4"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2023.122132"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens11101150"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.4103\/jomfp.JOMFP_304_18"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00542-10"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.5005\/jp-journals-10024-1477"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1089\/dna.2009.0874"},{"key":"e_1_2_10_19_1","first-page":"65","article-title":"Chemotherapy of dental plaque infections","volume":"9","author":"Loesche WJ","year":"1976","journal-title":"Oral Sci Rev"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1998.tb02419.x"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bdj.2016.865"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1128\/msystems.00187-18"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4614-6418-1_13-5"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/1365-2656.13229"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1159\/000499037"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01237-17"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-121918"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/ismej.2011.169"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-018-0175-4"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2024.1358179"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aau3333"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2017.06.002"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0902-0055.2001.00100.x"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1080\/20002297.2019.1586423"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2021.103701"},{"issue":"1","key":"e_1_2_10_36_1","first-page":"3","article-title":"High throughput sequencing detect gingivitis and periodontal oral bacteria in Alzheimer's disease autopsy brains","volume":"1","author":"Siddiqui H","year":"2019","journal-title":"J Neurosci Res"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.14348"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-220627"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.31254"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2017.00327"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.14283\/jpad.2023.82"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13016"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-215520"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.71879"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13776"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.14110"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/s44400-025-00004-4"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1080\/20002297.2023.2173544"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-190587"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1093\/pnasnexus\/pgae543"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13997"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13880"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.3390\/dj13060227"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2025.03.033"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2021.631770"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2025.1556688"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdi.12087"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2009.02.013"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-161256"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-020-02441-x"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2014.06.010"},{"issue":"2","key":"e_1_2_10_62_1","first-page":"883","article-title":"Comparison of oral microflora of diabetic and non\u2010diabetic patients with periodontitis","volume":"5","author":"Reena Kulshrestha RK","year":"2011","journal-title":"J Pure Appl Microbiol"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034518805739"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.02821-13"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm8010076"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034520913818"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.763334"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.2008.0363"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2023.1103052"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep42818"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2023.06.013"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-024-05135-3"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.52586\/S550"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens13010093"},{"key":"e_1_2_10_75_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01012-14"},{"key":"e_1_2_10_76_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.119.13664"},{"key":"e_1_2_10_77_1","doi-asserted-by":"publisher","DOI":"10.2147\/CIA.S400527"},{"key":"e_1_2_10_78_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A5143"},{"key":"e_1_2_10_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.06.2857"},{"issue":"6","key":"e_1_2_10_80_1","first-page":"680","article-title":"Effect of global brain ischemia on amyloid precursor protein metabolism and expression of amyloid\u2010degrading enzymes in rat cortex: role in pathogenesis of Alzheimer's disease","volume":"86","author":"Babusikova E","year":"2021","journal-title":"Biochemistry"},{"key":"e_1_2_10_81_1","doi-asserted-by":"publisher","DOI":"10.2147\/DMSO.S325073"},{"key":"e_1_2_10_82_1","doi-asserted-by":"publisher","DOI":"10.1080\/20002297.2025.2459919"},{"key":"e_1_2_10_83_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu15092074"},{"key":"e_1_2_10_84_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e328338cd36"},{"key":"e_1_2_10_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2013.04.023"},{"key":"e_1_2_10_86_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40292-019-00322-8"},{"key":"e_1_2_10_87_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-023-04247-8"},{"key":"e_1_2_10_88_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.121.021930"},{"key":"e_1_2_10_89_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1438726"},{"key":"e_1_2_10_90_1","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens9110944"},{"key":"e_1_2_10_91_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms7100424"},{"key":"e_1_2_10_92_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034513487559"},{"key":"e_1_2_10_93_1","doi-asserted-by":"publisher","DOI":"10.1080\/20002297.2022.2145729"},{"key":"e_1_2_10_94_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.16064"},{"key":"e_1_2_10_95_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0722.2004.00153.x"},{"key":"e_1_2_10_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2012.11.013"},{"key":"e_1_2_10_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.niox.2020.11.002"},{"key":"e_1_2_10_98_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345211064571"},{"key":"e_1_2_10_99_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-021-01606-z"},{"key":"e_1_2_10_100_1","doi-asserted-by":"publisher","DOI":"10.1128\/aem.63.3.924-930.1997"},{"key":"e_1_2_10_101_1","doi-asserted-by":"publisher","DOI":"10.3934\/microbiol.2018.1.42"},{"key":"e_1_2_10_102_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms11102550"},{"key":"e_1_2_10_103_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells10102581"},{"key":"e_1_2_10_104_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms13040814"},{"key":"e_1_2_10_105_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0234659"},{"key":"e_1_2_10_106_1","doi-asserted-by":"publisher","DOI":"10.1093\/ckj\/sfae294"},{"key":"e_1_2_10_107_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-016-0226-6"},{"key":"e_1_2_10_108_1","doi-asserted-by":"publisher","DOI":"10.1093\/ckj\/sfac020"},{"key":"e_1_2_10_109_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-63350-y"},{"key":"e_1_2_10_110_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu8050291"},{"key":"e_1_2_10_111_1","doi-asserted-by":"publisher","DOI":"10.1128\/spectrum.00598-24"},{"key":"e_1_2_10_112_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-016-0222-x"},{"key":"e_1_2_10_113_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.1602-23"},{"key":"e_1_2_10_114_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2010.384"},{"key":"e_1_2_10_115_1","doi-asserted-by":"publisher","DOI":"10.1038\/kisup.2014.21"},{"key":"e_1_2_10_116_1","doi-asserted-by":"publisher","DOI":"10.1111\/omi.12065"},{"key":"e_1_2_10_117_1","doi-asserted-by":"publisher","DOI":"10.1080\/20002297.2017.1300366"},{"key":"e_1_2_10_118_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ekir.2017.08.018"},{"key":"e_1_2_10_119_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-022-01443-4"},{"key":"e_1_2_10_120_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2024-334634"},{"key":"e_1_2_10_121_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2013080905"},{"key":"e_1_2_10_122_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-46888-3"},{"key":"e_1_2_10_123_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfae266"},{"key":"e_1_2_10_124_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1004472"},{"key":"e_1_2_10_125_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2024.02.012"},{"key":"e_1_2_10_126_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12368"},{"key":"e_1_2_10_127_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-017-0457-1"},{"key":"e_1_2_10_128_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms12091878"},{"key":"e_1_2_10_129_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e40663"},{"key":"e_1_2_10_130_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2025.101980"},{"key":"e_1_2_10_131_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep38993"},{"key":"e_1_2_10_132_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2020.104708"},{"key":"e_1_2_10_133_1","doi-asserted-by":"publisher","DOI":"10.1080\/20002297.2018.1442986"},{"key":"e_1_2_10_134_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aat0797"},{"key":"e_1_2_10_135_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-020-0409-1"},{"key":"e_1_2_10_136_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.24622"},{"key":"e_1_2_10_137_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aaj1921"},{"key":"e_1_2_10_138_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2019.08.007"},{"key":"e_1_2_10_139_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-023-03995-x"},{"key":"e_1_2_10_140_1","doi-asserted-by":"publisher","DOI":"10.3390\/children9111764"},{"key":"e_1_2_10_141_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu15040942"},{"key":"e_1_2_10_142_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0260384"},{"key":"e_1_2_10_143_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00803-13"},{"key":"e_1_2_10_144_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-64976-8"},{"key":"e_1_2_10_145_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.713647"},{"key":"e_1_2_10_146_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sjbs.2020.04.040"},{"key":"e_1_2_10_147_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines10030671"},{"key":"e_1_2_10_148_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.43.11.5721-5732.2005"},{"key":"e_1_2_10_149_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.2c00431"},{"key":"e_1_2_10_150_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-022-01637-0"},{"key":"e_1_2_10_151_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2024.177022"},{"key":"e_1_2_10_152_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9072042"},{"key":"e_1_2_10_153_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu14010020"},{"key":"e_1_2_10_154_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu13030732"},{"key":"e_1_2_10_155_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2020.572912"},{"key":"e_1_2_10_156_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina47030019"},{"key":"e_1_2_10_157_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-015-0291-y"},{"key":"e_1_2_10_158_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12393"},{"key":"e_1_2_10_159_1","doi-asserted-by":"publisher","DOI":"10.1093\/advances\/nmaa181"},{"key":"e_1_2_10_160_1","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2025.2486518"},{"key":"e_1_2_10_161_1","unstructured":"OrviskaP Role patogenu p\u0159i v\u00fdvoji Alzheimerovy nemoci."}],"container-title":["Alzheimer's &amp; Dementia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.71011","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/alz.71011","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.71011","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T03:39:24Z","timestamp":1780285164000},"score":1,"resource":{"primary":{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1002\/alz.71011"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":160,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1002\/alz.71011"],"URL":"https:\/\/doi.org\/10.1002\/alz.71011","archive":["Portico"],"relation":{},"ISSN":["1552-5260","1552-5279"],"issn-type":[{"value":"1552-5260","type":"print"},{"value":"1552-5279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"2025-07-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71011"}}