{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T12:26:54Z","timestamp":1788611214604,"version":"build-2803163510"},"reference-count":67,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T00:00:00Z","timestamp":1769731200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T00:00:00Z","timestamp":1769731200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>\n                      We investigated stage\u2010specific alterations in functional connectivity (FC) of the default mode network (DMN) across the Alzheimer's disease (AD) continuum and tested whether early amyloid beta (A\u03b2)\u2013related changes in within\u2010DMN FC (DMN\u2010FC\n                      <jats:sub>within<\/jats:sub>\n                      ) predicted longitudinal alterations in DMN between\u2010network connectivity (DMN\u2010FC\n                      <jats:sub>between<\/jats:sub>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      Resting\u2010state functional magnetic resonance imaging (fMRI) data were analyzed from 396 older adults: A\u03b2\u2010negative cognitively normal (CN\u2212,\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0213), A\u03b2\u2010positive CN (CN+,\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a037), A\u03b2\u2010positive mild cognitive impairment (MCI+,\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a072), and A\u03b2\u2010positive dementia (dementia+,\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a074). Cross\u2010sectional analyses compared DMN\u2010FC across groups and examined associations with continuous A\u03b2 burden at baseline. Longitudinal analyses in 171 CN participants with 2\u2010year follow\u2010up (CN\u2212,\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0147; CN+,\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a024) tested whether baseline DMN\u2010FC\n                      <jats:sub>within<\/jats:sub>\n                      predicted changes in DMN\u2010FC\n                      <jats:sub>between<\/jats:sub>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      CN+ individuals showed elevated DMN\u2010FC\n                      <jats:sub>within<\/jats:sub>\n                      and reduced DMN\u2010FC\n                      <jats:sub>between<\/jats:sub>\n                      relative to other groups. In CN, A\u03b2 burden was associated with FC, and baseline DMN\u2010FC\n                      <jats:sub>within<\/jats:sub>\n                      predicted longitudinal increases in DMN\u2010FC\n                      <jats:sub>between<\/jats:sub>\n                      only in CN+.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>A\u03b2\u2010related hyperconnectivity characterizes preclinical AD and may drive progressive network\u2010level vulnerability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Cognitively normal amyloid beta (A\u03b2)\u2013positive (CN+) individuals showed stronger connectivity within the default mode network (DMN).<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>CN+ individuals also showed weaker links between the DMN and other brain networks.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Amyloid was not linked to connectivity changes in cognitively impaired adults.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Higher DMN connectivity predicted broader network changes in CN+ individuals.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  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