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artificial intelligence (AI)\u2010assisted virtual reality (VR) cognitive scores with plasma amyloid beta (A\u03b2)\n                      <jats:sub>42<\/jats:sub>\n                      \/A\u03b2\n                      <jats:sub>40<\/jats:sub>\n                      , phosphorylated tau (p\u2010tau)\n                      <jats:sub>217<\/jats:sub>\n                      , glial fibrillary acidic protein (GFAP), neurofilament light chain (NfL), A\u03b2 positron emission tomography (PET), tau PET, neurodegeneration, and cognition using generalized linear models, including age, sex, education, and apolipoprotein E \u03b54 as covariates.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      The AI\u2010VR cognitive scores were significantly correlated with plasma A\u03b2\n                      <jats:sub>42<\/jats:sub>\n                      \/A\u03b2\n                      <jats:sub>40<\/jats:sub>\n                      , p\u2010tau\n                      <jats:sub>217<\/jats:sub>\n                      , GFAP, NfL, A\u03b2 PET, tau PET, hippocampal atrophy, temporal meta\u2010region of interest cortical thinning, and cortical mean diffusivity increases, accurately identifying cognitively impaired patients from unimpaired individuals (area under curve [AUC]: 0.908\u20130.969) as well as classifying A\u03b2 PET\u2013positive individuals from negative group (AUC: 0.771\u20130.991).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>This study comprehensively examined the capacity of a 5\u2010minute AI\u2010VR cognitive test for identifying abnormal cognition and AD biomarkers, offering a reliable digital marker for early AD detection in community settings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Digital virtual\u2010reality cognitive tests correlate with AD biomarkers<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Digital virtual\u2010reality cognitive tests can identify cognitive impairment<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Digital virtual\u2010reality cognitive tests can classify those who are amyloid beta positron emission tomography positive from negative.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  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