{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T14:30:11Z","timestamp":1786113011510,"version":"build-2736575974"},"reference-count":54,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T00:00:00Z","timestamp":1767139200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T00:00:00Z","timestamp":1767139200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U22A20300 82371434"],"award-info":[{"award-number":["U22A20300 82371434"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>With the approval of lecanemab for treating Alzheimer's disease (AD), there is an urgent need to evaluate its safety and treatment effects on biomarkers in real\u2010world practice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      Patients receiving lecanemab (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a072) underwent routine 3T and 7T magnetic resonance imaging (MRI) for amyloid\u2010related imaging abnormality (ARIA) monitoring. Longitudinal changes of iron deposition assessed by quantitative susceptibility mapping (QSM) and its association with plasma biomarkers were further evaluated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>With use of 7T MRI, we identified characteristic perivascular features and detected ARIA with hemorrhages\/hemosiderin deposition (ARIA\u2010H) \u22484 months earlier than with 3T. QSM detected post\u2010treatment regional susceptibility reductions. Decreased susceptibility in the temporal, frontal lobes, and the thalamus was associated with plasma amyloid beta 42 (A\u03b242) and tau phosphorylated at threonine 217 (p\u2010tau217) changes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>7T MRI provides superior ARIA\u2010H detection and iron dynamics monitoring, supporting its role in risk stratification and therapy assessment for lecanemab\u2010treated patients. Iron deposition measured by QSM may serve as a promising neuroimaging marker for amyloid\u2010targeting treatments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Using 7T magnetic resonance imaging (MRI), this study for the first time visualized amyloid\u2010related imaging abnormality with hemorrhages\/hemosiderin deposition (ARIA\u2010H) at a submillimeter resolution, characterized by aggregated, clustered cerebral microbleeds in a perivascular distribution, suggesting overlapping pathology with cerebral amyloid angiopathy.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>The susceptibility\u2010weighted imaging sequence on 7T MRI enabled detection of ARIA\u2010H up to 4 months earlier.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Plasma amyloid beta 42 (A\u03b242) and tau phosphorylated at threonine 217 (p\u2010tau 217) levels are sensitive biomarkers for amyloid targeted therapy.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Quantitative susceptibility mapping (QSM) analysis demonstrated reduced cortical iron burden post\u2010treatment, which has significant associations with plasma A\u03b242 and p\u2010tau 217 levels, highlighting QSM\u2010derived iron quantification as a promising neuroimaging indicator for amyloid\u2010targeted therapeutics.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71044","type":"journal-article","created":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T03:40:53Z","timestamp":1767238853000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Six\u2010month follow\u2010up of ARIA\u2010H and iron deposition in real\u2010world lecanemab therapy for Alzheimer's disease: Evidence from a Chinese 7T MRI cohort"],"prefix":"10.1002","volume":"22","author":[{"given":"Weiwei","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Radiology Xiangya Hospital Central South University  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haokun","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurology Xiangya Hospital Central South University  Changsha Hunan 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