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The occurrence of herpesvirus genome integration in dementia patients has not been thoroughly characterized.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>Over 7500 total whole\u2010genome sequences from control, frontotemporal dementia\/amyotrophic lateral sclerosis spectrum, Lewy body dementia (LBD), multiple system atrophy (MSA), and AD cohorts were screened for the integration of pathogen genomes using the PathSeq computational tool.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Low PathSeq scores for human herpesvirus 6 (HHV\u20106) were consistent with the suspected integration of viral genome segments. The LBD and MSA cohorts had a significantly higher prevalence of this partial HHV\u20106 genome integration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>This higher prevalence in both synucleinopathies was not noted in other herpesviruses, suggesting that the integration of HHV\u20106 may play a role in a subset of these patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Over 7500 whole\u2010genome sequences from controls and dementia patients were analyzed.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Sequences consistent with integrated herpesviruses were identified using PathSeq.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Prevalence of partial HHV\u20106 integration was higher in synucleinopathies.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Herpesviruses genome integration may play a role in subsets of dementia patients.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71047","type":"journal-article","created":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T09:47:46Z","timestamp":1773913666000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Herpesvirus genome integration in whole\u2010genome sequences of dementia and control 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