{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T10:24:20Z","timestamp":1789035860478,"version":"build-2803163510"},"reference-count":59,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T00:00:00Z","timestamp":1766707200000},"content-version":"vor","delay-in-days":25,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100009408","name":"Fondation Brain Canada","doi-asserted-by":"publisher","award":["CFI Project 34874"],"award-info":[{"award-number":["CFI Project 34874"]}],"id":[{"id":"10.13039\/100009408","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009408","name":"Fondation Brain Canada","doi-asserted-by":"publisher","award":["33397"],"award-info":[{"award-number":["33397"]}],"id":[{"id":"10.13039\/100009408","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>\n                      It is unclear whether the different Alzheimer's disease (AD) progression trajectories of apolipoprotein E (\n                      <jats:italic>APOE<\/jats:italic>\n                      ) \u025b4 carriers is reflected by blood phosphorylated tau (p\u2010tau) analytes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      We assessed longitudinal trajectories in plasma p\u2010tau181, 217, and 231, in amyloid beta\u2013positive (A+) and negative (A\u2212)\n                      <jats:italic>APOE<\/jats:italic>\n                      \u025b4 carriers (E+) or non\u2010carriers (E\u2013). We included 2039 participants from the observational Translational Biomarkers in Aging and Dementia (TRIAD) and Alzheimer's Disease Neuroimaging Initiative cohorts, categorized into 840 A\u2212E\u2013, 251 A\u2013E+, 386 A+E4\u2212, and 616 A+E4+. Longitudinal data were available for 1045 participants.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      In TRIAD, ALZpath p\u2010tau217 (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u00a0=\u00a00.45,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.02) and p\u2010tau217+\n                      <jats:sup>Janssen<\/jats:sup>\n                      (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u00a0=\u00a00.67,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.002), and in ADNI p\u2010tau217 (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u00a0=\u00a00.90,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.002) increased faster in A+E4+. This was not the case in E\u2013 or A\u2013 individuals or for p\u2010tau181 and p\u2010tau231.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>\n                      These findings suggest p\u2010tau217 as a marker of faster progression in\n                      <jats:italic>APOE<\/jats:italic>\n                      \u025b4 carriers, highlighting its potential in disease stratification.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>\n                            Blood phosphorylated tau (p\u2010tau)217 increases faster in apolipoprotein E (\n                            <jats:italic>APOE<\/jats:italic>\n                            ) \u025b4 carriers with amyloid pathology.\n                          <\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>\n                            p\u2010tau181 and p\u2010tau231 do not increase faster in\n                            <jats:italic>APOE<\/jats:italic>\n                            \u025b4 carriers.\n                          <\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>\n                            <jats:italic>APOE<\/jats:italic>\n                            \u025b4 carriership does not change p\u2010tau in individuals without amyloid pathology.\n                          <\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71048","type":"journal-article","created":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T11:33:15Z","timestamp":1766748795000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["<i>APOE<\/i>\n                    \u025b4 carriership determines a faster plasma p\u2010tau217 progression in A\u03b2\u2010positive individuals"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1306-2708","authenticated-orcid":false,"given":"Marcel S.","family":"Woo","sequence":"first","affiliation":[{"name":"Translational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging, McConnell Brain Imaging Centre (BIC) Montreal Neurological Institute  Montr\u00e9al Quebec Canada"},{"name":"Translational Neurodegeneration Laboratory, Department of Neurology University Medical Centre Hamburg Eppendorf  Hamburg Germany"},{"name":"Institute of Neuroimmunology and Multiple Sclerosis University Medical Centre Hamburg Eppendorf  Hamburg Germany"},{"name":"Department of Neurology and Neurosurgery McGill University  Montr\u00e9al Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur C","family":"Macedo","sequence":"additional","affiliation":[{"name":"Translational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging, McConnell Brain Imaging Centre (BIC) Montreal Neurological Institute  Montr\u00e9al Quebec Canada"},{"name":"Department of Neurology and Neurosurgery McGill University  Montr\u00e9al Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyyed Ali","family":"Hosseini","sequence":"additional","affiliation":[{"name":"Translational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging, McConnell Brain Imaging Centre (BIC) Montreal Neurological Institute  Montr\u00e9al Quebec Canada"},{"name":"Department 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