{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T12:15:14Z","timestamp":1790252114781,"version":"4.1.0"},"reference-count":70,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T00:00:00Z","timestamp":1766707200000},"content-version":"vor","delay-in-days":25,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100008947","name":"Stiftung Synapsis - Alzheimer Forschung Schweiz AFS","doi-asserted-by":"publisher","award":["2017\u2010PI01"],"award-info":[{"award-number":["2017\u2010PI01"]}],"id":[{"id":"10.13039\/501100008947","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["320030_204886"],"award-info":[{"award-number":["320030_204886"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["320030_141179"],"award-info":[{"award-number":["320030_141179"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp; Dementia"],"published-print":{"date-parts":[[2025,12]]},"abstract":"Abstract<\/jats:title>\n \n BACKGROUND<\/jats:title>\n Depressive symptoms are common in cognitive decline and Alzheimer's disease (AD), but their underlying pathology remains poorly understood. We aimed to investigate the pathophysiology of depressive symptoms in the context of AD.<\/jats:p>\n <\/jats:sec>\n \n METHODS<\/jats:title>\n Individuals with normal cognition (NC), mild cognitive impairment (MCI), or mild AD dementia from two independent, large cohorts were included. Untargeted mass spectrometry\u2013based cerebrospinal fluid (CSF) proteomics, regression analyses, and pathway\u2010enrichment analyses were applied.<\/jats:p>\n <\/jats:sec>\n \n RESULTS<\/jats:title>\n A total of 688 individuals (223 NC, 190 MCI, and 275 AD dementia) were included. The levels of 57 out of 946 robustly quantified CSF proteins were associated with depressive symptoms consistently across both cohorts. These proteins were enriched for cell adhesion\/inflammation, synaptic signaling, and neurogenesis. In amyloid\u2010positive subjects, cholesterol metabolism and transport were additionally associated with depressive symptoms.<\/jats:p>\n <\/jats:sec>\n \n CONCLUSION<\/jats:title>\n The identified proteome alterations may reflect shared biological mechanisms involved in both AD and depression in older people.<\/jats:p>\n <\/jats:sec>\n \n Highlights<\/jats:title>\n \n \n \n This is the first study to investigate cerebrospinal fluid proteome alterations associated with depressive symptoms in the context of cognitive decline and Alzheimer's disease (AD).<\/jats:p>\n <\/jats:list-item>\n \n Dysregulated proteins in patients with higher depression scores were related to pathways linked to cell adhesion\/inflammation, synaptic signaling, and neurogenesis, as well as cholesterol metabolism in amyloid\u2010positive individuals.<\/jats:p>\n <\/jats:list-item>\n \n The identified proteome alterations may represent shared biological mechanisms involved in both AD and depression in older people.<\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/alz.71054","type":"journal-article","created":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T11:28:18Z","timestamp":1766748498000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Cerebrospinal fluid proteome alterations related to depressive symptoms in cognitive decline and Alzheimer's disease"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3189-6554","authenticated-orcid":false,"given":"Miriam","family":"Rabl","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Psychotherapy Psychiatric University Hospital Zurich University of Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-9936-3472","authenticated-orcid":false,"given":"Willem L.","family":"Hartog","sequence":"additional","affiliation":[{"name":"Alzheimer Center Amsterdam Department of Neurology Vrije Universiteit Amsterdam Amsterdam UMC Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8766-6224","authenticated-orcid":false,"given":"Wiesje M.","family":"van der Flier","sequence":"additional","affiliation":[{"name":"Amsterdam Neuroscience Neurodegeneration Amsterdam UMC Amsterdam the Netherlands"},{"name":"Epidemiology and Data Science Vrije Universiteit Amsterdam Amsterdam UMC location VUmc Amsterdam the Netherlands"},{"name":"Alzheimer Nederland Amersfoort the Netherlands"},{"name":"Amsterdam Public Health Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2464-1905","authenticated-orcid":false,"given":"Yolande A. L.","family":"Pijnenburg","sequence":"additional","affiliation":[{"name":"Alzheimer Center Amsterdam Department of Neurology Vrije Universiteit Amsterdam Amsterdam UMC Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4061-0837","authenticated-orcid":false,"given":"Charlotte E.","family":"Teunissen","sequence":"additional","affiliation":[{"name":"Neurochemistry Laboratory Department of Laboratory Medicine Amsterdam Neuroscience Vrije Universiteit Amsterdam Amsterdam UMC Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2072-8010","authenticated-orcid":false,"given":"Magda","family":"Tsolaki","sequence":"additional","affiliation":[{"name":"Department of Caregiver's Support Greek Association of Alzheimer's Disease and Related Disorders (GAADRD) Thessaloniki Greece"},{"name":"Laboratory of Neurodegenerative Diseases Center for Interdisciplinary Research and Innovation (CIRI\u2010AUTH) Balkan Center Aristotle University of Thessaloniki Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6863-6679","authenticated-orcid":false,"given":"Yvonne","family":"Freund\u2010Levi","sequence":"additional","affiliation":[{"name":"Department of Clinical Science and Education S\u00f6dersjukhuset Karolinska Institutet Stockholm Sweden"},{"name":"School of Medical Sciences \u00d6reebro University and Department of Psychiatry \u00d6rebro University Hospital \u00d6rebro Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6237-2502","authenticated-orcid":false,"given":"Rik","family":"Vandenberghe","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospitals Leuven Leuven Belgium"},{"name":"Laboratory for Cognitive Neurology KU Leuven Biomedical Sciences Group Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1494-0813","authenticated-orcid":false,"given":"Lutz","family":"Froelich","sequence":"additional","affiliation":[{"name":"Department of Geriatric Psychiatry Central Institute of Mental Health Medical Faculty Mannheim University of Heidelberg Mannheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9387-5951","authenticated-orcid":false,"given":"Johannes","family":"Streffer","sequence":"additional","affiliation":[{"name":"H. Lundbeck A\/S Valby Denmark"},{"name":"Formerly Janssen R&D Beerse Belgium"},{"name":"Department of Biomedical Sciences University of Antwerp Antwerp Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0473-4565","authenticated-orcid":false,"given":"Simon","family":"Lovestone","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Oxford Headington UK"},{"name":"Johnson and Johnson Medical Ltd. Wokingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0108-124X","authenticated-orcid":false,"given":"Lars","family":"Bertram","sequence":"additional","affiliation":[{"name":"L\u00fcbeck Interdisciplinary Platform for Genome Analytics (LIGA) University of L\u00fcbeck L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3930-4354","authenticated-orcid":false,"given":"Henrik","family":"Zetterberg","sequence":"additional","affiliation":[{"name":"Wisconsin Alzheimer's Disease Research Center School of Medicine and Public Health University of Wisconsin\u2013Madison Madison Wisconsin USA"},{"name":"Department of Psychiatry and Neurochemistry Institute of Neuroscience and Physiology the Sahlgrenska Academy at the University of Gothenburg M\u00f6lndal Sweden"},{"name":"Clinical Neurochemistry Laboratory Hus V3 Sahlgrenska University Hospital M\u00f6lndal Sweden"},{"name":"Department of Neurodegenerative Disease UCL Institute of Neurology London UK"},{"name":"UK Dementia Research Institute at UCL London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6193-6193","authenticated-orcid":false,"given":"Johan","family":"Gobom","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neurochemistry Institute of Neuroscience and Physiology the Sahlgrenska Academy at the University of Gothenburg M\u00f6lndal Sweden"},{"name":"Clinical Neurochemistry Laboratory Hus V3 Sahlgrenska University Hospital M\u00f6lndal Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2045-9818","authenticated-orcid":false,"given":"Stephanie J. B.","family":"Vos","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neuropsychology Alzheimer Centrum Limburg School for Mental Health and Neuroscience Maastricht University Maastricht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8008-9727","authenticated-orcid":false,"given":"Pieter Jelle","family":"Visser","sequence":"additional","affiliation":[{"name":"Alzheimer Center Amsterdam Department of Neurology Vrije Universiteit Amsterdam Amsterdam UMC Amsterdam the Netherlands"},{"name":"Department of Psychiatry and Neuropsychology Alzheimer Centrum Limburg School for Mental Health and Neuroscience Maastricht University Maastricht the Netherlands"},{"name":"Department of Neurobiology Care Sciences and Society Division of Neurogeriatrics Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2612-1797","authenticated-orcid":false,"given":"Betty M.","family":"Tijms","sequence":"additional","affiliation":[{"name":"Alzheimer Center Amsterdam Department of Neurology Vrije Universiteit Amsterdam Amsterdam UMC Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0068-0312","authenticated-orcid":false,"given":"Julius","family":"Popp","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy Psychiatric University Hospital Zurich University of Zurich Zurich Switzerland"},{"name":"Old\u2010Age Psychiatry Service Department of Psychiatry University Hospital Lausanne Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,26]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000012598"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12991-021-00375-x"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2015.09.069"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-024-01526-4"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2014.14040480"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-148004"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2009.10.022"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcpt.13996"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2022.1065904"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2013.01.029"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jprot.2022.104713"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.15715"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2024-333819"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2011.63"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-020-0825-7"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jproteome.8b00809"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2006.10.040"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-132306"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-018-0396-5"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181cb3e25"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2017.281055"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1080\/13607860902861027"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1300\/J018v05n01_09"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/geronj\/44.4.P124"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12713"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43587-023-00550-7"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M116.065524"},{"key":"e_1_2_11_29_1","unstructured":"LenthVR emmeans: estimated Marginal Means aka Least\u2010Squares Means.R package version 1.10.5\u20100900003 https:\/\/rvlenth.github.io\/emmeans\/2024"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gpb.2022.04.008"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2517-6161.1995.tb02031.x"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkac1000"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btz931"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btq064"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181e62138"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1080\/14789450.2017.1336435"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2011.285"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-022-01806-1"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21030701"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/6427537"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2018.11.006"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1177\/030098589703400113"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2015.06.001"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2015.5"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scib.2024.09.041"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-023-02964-x"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.2174\/1570159X14666151208113700"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1807-59322011001300002"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-801977-1.00008-8"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2011.220"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2024.4305"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/dad2.12106"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1566067"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2006.03759.x"},{"key":"e_1_2_11_55_1","first-page":"161","article-title":"Novel insights into the physiological function of the APP (Gene) family and its proteolytic fragments in synaptic plasticity","volume":"9","author":"Ludewig S","year":"2016","journal-title":"Front Mol Neurosci"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1042\/BST20221527"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.2174\/1567205014666170317113606"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2014.09.003"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S385825"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2012.07893.x"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2666-7568(21)00150-1"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2013.5390"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.5607\/en23010"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2024.4525"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2024-334925"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12944-025-02512-x"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-020-0621-y"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-023-04727-x"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.70025"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.csbj.2022.08.037"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky1106"}],"container-title":["Alzheimer's & Dementia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.71054","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/alz.71054","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.71054","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T03:38:47Z","timestamp":1780285127000},"score":1,"resource":{"primary":{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1002\/alz.71054"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":70,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1002\/alz.71054"],"URL":"https:\/\/doi.org\/10.1002\/alz.71054","archive":["Portico"],"relation":{},"ISSN":["1552-5260","1552-5279"],"issn-type":[{"value":"1552-5260","type":"print"},{"value":"1552-5279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"2025-09-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71054"}}