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Studies of Memory in an International Consortium study). Apathy, depression, and dementia outcomes were assessed using harmonization protocols.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Over 5.7 years of follow\u2010up, 1160 developed dementia and 552 Alzheimer's disease (AD). Apathy prevalence was 34.1% and more than three times higher in those with depression. Apathy was not associated with dementia risk among cognitively normal or non\u2010depressed individuals. In contrast, among individuals with depression and mild cognitive impairment (MCI), apathy predicted a higher risk of dementia (hazard ratio [HR] 1.62) and AD (HR 1.74).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Apathy is associated with increased dementia risk only in older adults with MCI and depression. Findings highlight the need to incorporate affective symptom monitoring into dementia risk assessment and intervention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Harmonized data from 10 population\u2010based cohorts across six continents were used.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Apathy predicted dementia only in older adults with both depression and mild cognitive impairment.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>No association was found in non\u2010depressed or cognitively normal individuals.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Monitoring progression of affective symptoms may aid dementia risk stratification.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71059","type":"journal-article","created":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T09:20:02Z","timestamp":1767000002000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Apathy, depression, and dementia risk in older adults: A global collaborative study"],"prefix":"10.1002","volume":"21","author":[{"given":"Dae Jong","family":"Oh","sequence":"first","affiliation":[{"name":"Workplace Mental Health Institute Kangbuk Samsung Hospital Sungkyunkwan University School of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darren 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