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Amyloid beta (A\u03b2) on positron emission tomography, hippocampal atrophy, and dorsolateral prefrontal cortex thickness on MRI were assessed 10 years after completion of the mHT trial (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0266).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>A\u03b2 and structural MRI biomarkers were not different in the oCEE and tE2 groups compared to placebo. Apolipoprotein E \u03b54 status did not modify the findings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>There was no evidence of adverse effects or benefits associated with 4 years of use of oral or transdermal mHT on A\u03b2 and structural MRI biomarkers in relatively healthy women, 10 years after mHT. Findings support the long\u2010term safety of short\u2010term use of mHT on brain health.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CLINICAL TRIALS REGISTRATION<\/jats:title>\n                    <jats:p>NCT00154180 Kronos Early Estrogen Prevention Study (KEEPS)<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>There were no menopausal hormone therapy\u2013related adverse effects or benefits on amyloid beta and magnetic resonance imaging biomarkers in the long term.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Apolipoprotein E \u03b54 carrier status did not modify these findings.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Findings align with neutral cognitive and cerebrovascular outcomes in this cohort.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71067","type":"journal-article","created":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T09:53:53Z","timestamp":1769853233000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Long\u2010term amyloid PET and MRI outcomes in a menopausal hormone therapy trial"],"prefix":"10.1002","volume":"22","author":[{"given":"Kejal","family":"Kantarci","sequence":"first","affiliation":[{"name":"Department of Radiology Mayo Clinic  Rochester Minnesota 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