{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T14:19:59Z","timestamp":1786112399180,"version":"build-2736575974"},"reference-count":42,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T00:00:00Z","timestamp":1767744000000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012149","name":"National Key Scientific Instrument and Equipment Development Projects of China","doi-asserted-by":"publisher","award":["31627803"],"award-info":[{"award-number":["31627803"]}],"id":[{"id":"10.13039\/501100012149","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp; Dementia"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>The association between genetic predisposition to dyslipidemia and dementia risk is inconsistent. It remains unknown whether a physically active lifestyle is associated with a lower dementia risk across different levels of this genetic predisposition.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>We analyzed 198,448 White participants (aged \u2265 60 years) with a median 14.8\u2010year follow\u2010up in UK Biobank. We used Cox proportional hazards models to assess associations between dyslipidemia polygenic risk scores (PRSs), physical activity, and incident dementia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Higher low\u2010density lipoprotein cholesterol PRS and lower high\u2010density lipoprotein cholesterol PRS were associated with increased risk of all\u2010cause dementia, Alzheimer's disease, and vascular dementia (VaD). Being physically active was associated with lower risk of all\u2010cause dementia and VaD. This beneficial association of a physically active lifestyle was observed across all genetic risk strata and was most pronounced for VaD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Regular physical activity may be a promising strategy for dementia prevention, even in individuals with high genetic risk of dyslipidemia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Genetic predisposition to higher low\u2010density lipoprotein cholesterol and lower high\u2010density lipoprotein cholesterol is linked to increased dementia risk.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Being physically active is associated with lower dementia risk across genetic risk profiles.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Being physically active shows the strongest association with lower risk of vascular dementia.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71079","type":"journal-article","created":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T17:37:10Z","timestamp":1767807430000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Association of genetic predisposition to dyslipidemia and physical activity with incident dementia"],"prefix":"10.1002","volume":"22","author":[{"given":"Yumei","family":"Liang","sequence":"first","affiliation":[{"name":"Innovation Center for Neurological Disorders and Department of Neurology National Clinical Research Center for Geriatric Diseases Xuanwu Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siqi","family":"Xie","sequence":"additional","affiliation":[{"name":"Innovation Center for Neurological Disorders and Department of Neurology National Clinical Research Center for Geriatric Diseases Xuanwu Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dandan","family":"Sheng","sequence":"additional","affiliation":[{"name":"Innovation Center for Neurological Disorders and Department of Neurology National Clinical Research Center for Geriatric Diseases Xuanwu Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Ding","sequence":"additional","affiliation":[{"name":"Innovation Center for Neurological 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