{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T04:09:20Z","timestamp":1791950960952,"version":"4.3.4"},"reference-count":44,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T00:00:00Z","timestamp":1776816000000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Aging is the strongest risk factor for Alzheimer's disease (AD) characterized by amyloid\u2010\u03b2 (A\u03b2) plaques and tau tangles in the brain. We aim to compare biological aging\u2010related biomarkers among AD, non\u2010neurodegenerative control (NDC) and non\u2010AD neurodegenerative (Non\u2010AD) individuals to evaluate their clinical utility.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>We included 137 participants (37 NDC, 67 AD, 33 Non\u2010AD) from the University College London (UCL) Dementia Research Centre and measured matrix metallopeptidase 10 (MMP\u201010), osteopontin (OPN), neurofilament\u2010light, and glial fibrillary acidic protein in cerebrospinal fluid (CSF) in addition to A\u03b2\/pTau and clinical parameters.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Elevated MMP\u201010 associated with poorer cognition and later onset specifically in AD, whereas elevated OPN associated with A\u03b2 and tau pathology. MMP\u201010 and OPN levels improved the differentiation of AD from NDC, and AD from Non\u2010AD, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Our study provides evidence on potential clinical utility of CSF MMP\u201010 and OPN in diagnosis and supports taking biological aging into consideration in AD research.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Elevated osteopontin and matrix metallopeptidase 10 (MMP\u201010) levels in Alzheimer's disease (AD) cerebrospinal fluid.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>MMP\u201010 levels are linked to age at onset and cognitive decline.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Osteopontin levels are linked to AD pathologies in the cerebrospinal fluid.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>MMP\u201010 levels improved discrimination of AD from non\u2010neurodegenerative controls.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Osteopontin levels improved discrimination of AD from other neurodegenerative cases.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71082","type":"journal-article","created":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T03:34:27Z","timestamp":1776915267000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Aging\u2010related matrix metallopeptidase 10 and osteopontin levels are associated with pathology, cognitive decline, and age at onset in Alzheimer's disease"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6819-0176","authenticated-orcid":false,"given":"Bryan","family":"Ng","sequence":"first","affiliation":[{"name":"UK Dementia Research Institute, Cruciform Building University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleftheria","family":"Kodosaki","sequence":"additional","affiliation":[{"name":"UK Dementia Research Institute, Cruciform Building University College London  London UK"},{"name":"Department of 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