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Triacylglycerols (TAGs) and lipid droplets (LDs) were more abundant in the AD donors compared to the resilient donors. Multi\u2010omics factor analysis (MOFA) showed that increased \u03c96\u2010derived oxylipins and the loss of inhibitory neurons were associated with amyloid beta (A\u03b2) plaque load.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Our multi\u2010omics data show a molecular response associated with A\u03b2 load shared among AD and resilient donors, but reduced LDs in resilient donors compared to AD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Comprehensive lipidomics analysis of frontal cortex from controls, Alzheimer's disease (AD) patients and resilient individuals.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>\u03c96 Oxylipins, markers of neuroinflammation, are increased in both AD and resilience.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Resilient donors have reduced triacylglycerols and lipid droplets compared to AD.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Multi\u2010omics integration shows a molecular response to amyloid beta plaques associated with \u03c96\u2010derived oxylipins and loss of interneurons.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71083","type":"journal-article","created":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T08:16:16Z","timestamp":1770106576000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Reduced triacylglycerols and lipid droplets are associated with resilience to Alzheimer's disease"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7317-9679","authenticated-orcid":false,"given":"Daan","family":"van der Vliet","sequence":"first","affiliation":[{"name":"Department of Molecular Physiology Leiden University &amp; Oncode Institute  Leiden The Netherlands"},{"name":"Department of Neuroimmunology Netherlands Institute for Neuroscience Institute of the Royal Netherlands Academy of Arts and Sciences  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luuk E.","family":"de Vries","sequence":"additional","affiliation":[{"name":"Department of Neuroregeneration Netherlands Institute for Neuroscience Royal Netherlands Academy of Arts and Sciences  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Di","sequence":"additional","affiliation":[{"name":"Department of Molecular Physiology Leiden University &amp; Oncode Institute  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis","family":"Wever","sequence":"additional","affiliation":[{"name":"Department of Neuroimmunology Netherlands Institute for Neuroscience Institute of the Royal Netherlands Academy of Arts and Sciences  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brechtje","family":"de Jong","sequence":"additional","affiliation":[{"name":"Department of Molecular Physiology Leiden University &amp; Oncode Institute  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc T. 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