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Identifying predictive biomarkers for non\u2010amyloid\u2010related CI may provide better screening tests for trials seeking only CI A\u03b2+ participants and new therapy targets.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      Analysis of the Bio\u2010Hermes biomarker database identified subpopulations of clinically normal, CN A\u03b2\u2212 (\n                      <jats:italic>n\u00a0=\u00a0<\/jats:italic>\n                      313), CI A\u03b2\u2212 (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0296), and CI A\u03b2+ (\n                      <jats:italic>n\u00a0=<\/jats:italic>\n                      \u00a0258), and CN A\u03b2+ (\n                      <jats:italic>n\u00a0=\u00a0<\/jats:italic>\n                      84) participants. Comparative analysis of demographics, clinical assessments, biomarkers, cytokines, and proteomics results was conducted.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Subgroup comparison of CI A\u03b2\u2212 versus CN A\u03b2\u2212 found that neurofilament light most clearly differentiated CI A\u03b2\u2212 from CN A\u03b2\u2212 participants. No other biomarker analysis reached a level of differential significance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Analyses showed many novel biomarkers do not differentiate CI A\u03b2\u2212 from CN A\u03b2\u2212. New biomarkers are needed to best determine the neuropathology of the clinical presentation of AD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>NfL differentiated CN A\u03b2\u2212 versus cognitively impaired A\u03b2\u2212.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Proteomics (two platforms) did not differentially assess cognitively impaired A\u03b2\u2212\u2010.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Many novel biomarkers did not differentially assess cognitively impaired A\u03b2\u2212.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>New biomarkers are needed to determine the neuropathology of AD clinical presentation.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71085","type":"journal-article","created":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T03:35:49Z","timestamp":1769657749000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Biomarkers in patients with clinical signs of mild cognitive impairment or mild Alzheimer's disease but without amyloid deposits on positron emission tomography: Results from Bio\u2010Hermes Study participants"],"prefix":"10.1002","volume":"22","author":[{"given":"Richard C.","family":"Mohs","sequence":"first","affiliation":[{"name":"Global Alzheimer's Platform Foundation  Washington District of Columbia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas W.","family":"Beauregard","sequence":"additional","affiliation":[{"name":"Global Alzheimer's Platform Foundation  Washington District of Columbia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynne","family":"Hughes","sequence":"additional","affiliation":[{"name":"Global Alzheimer's Platform Foundation  Washington District of Columbia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyndy B.","family":"Cordell","sequence":"additional","affiliation":[{"name":"Global Alzheimer's Platform Foundation  Washington District of Columbia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan I.","family":"Levey","sequence":"additional","affiliation":[{"name":"Department of Neurology Emory University School of Medicine  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saima","family":"Rathore","sequence":"additional","affiliation":[{"name":"Department of Neurology Emory University School of Medicine  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas T.","family":"Seyfried","sequence":"additional","affiliation":[{"name":"Department of Neurology Emory University School of Medicine  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik C. 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