{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T07:48:55Z","timestamp":1782546535710,"version":"3.54.5"},"reference-count":65,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T00:00:00Z","timestamp":1769731200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T00:00:00Z","timestamp":1769731200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100014219","name":"National Science Fund for Distinguished Young Scholars","doi-asserted-by":"publisher","award":["82025013"],"award-info":[{"award-number":["82025013"]}],"id":[{"id":"10.13039\/501100014219","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp; Dementia"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>\n                      The apolipoprotein E \u03b54 (\n                      <jats:italic>APOE<\/jats:italic>\n                      \u03b54) allele is a major genetic risk factor for Alzheimer's disease, but its relevance to cognition in intracranial atherosclerosis (ICAS) remains unclear. We investigated the association between\n                      <jats:italic>APOE<\/jats:italic>\n                      \u03b54 and cognition in ICAS.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      Baseline data from a multicenter cohort were analyzed. Patients with radiologically confirmed ICAS underwent\n                      <jats:italic>APOE<\/jats:italic>\n                      genotyping, plasma biomarker assays, magnetic resonance imaging assessment of cerebral small vessel disease (CSVD) and brain atrophy, and standardized cognitive testing.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Among 409 patients (mean age 60 years, 55% male), 16% carried\n                      <jats:italic>APOE<\/jats:italic>\n                      \u03b54. Carriers showed more frequent cognitive impairment (63%\u00a0vs 48%), greater stenosis burden, and lower plasma amyloid beta (A\u03b2)42\/40 ratios, whereas other Alzheimer's biomarkers, CSVD burden, and atrophy scores showed no difference. After adjustment,\n                      <jats:italic>APOE<\/jats:italic>\n                      \u03b54remained associated with cognitive impairment (odds ratio [OR] 1.86). The association was pronounced in women (OR 4.43) but absent in men.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>\n                      <jats:italic>APOE<\/jats:italic>\n                      \u03b54 is linked to cognitive impairment in ICAS, particularly in women, through mechanisms beyond Alzheimer's pathology.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71087","type":"journal-article","created":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T04:42:38Z","timestamp":1769834558000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["<i>APOE4<\/i>\n                    and cognition in intracranial atherosclerosis: beyond Alzheimer's 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