{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T17:58:49Z","timestamp":1790013529660,"version":"4.0.1"},"reference-count":58,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T00:00:00Z","timestamp":1772236800000},"content-version":"vor","delay-in-days":27,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp; Dementia"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Associations of cardiac structure and function with longitudinal changes in cognitive function are not known.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>Among 4957 participants (age 75\u00a0\u00b1\u00a05 years) in the Atherosclerosis Risk in Communities study free of stroke, heart failure, and dementia who underwent protocol echocardiography and neurocognitive testing at study Visit 5 and repeat neurocognitive testing at three follow\u2010up visits over 10 years, factor scores were derived for executive function, memory, and language and averaged into a global score. We assessed associations using multivariable linear mixed models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Greater left ventricular mass index, higher left atrial (LA) volume index, and lower LA reservoir strain were associated with greater decline in global cognition (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.01), driven by decline in executive function. Lower ejection fraction and e\u2019 velocity associated with greater decline in memory.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Subclinical left ventricular remodeling and diastolic dysfunction are associated with greater decline in cognitive function over 10 years in late life.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>LV remodeling and diastolic dysfunction are associated with accelerated cognitive decline.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>This association is driven by associations with accelerated decline in EF.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Lower ejection fraction and e\u2032 velocity are associated with accelerated decline in memory.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71089","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T22:55:51Z","timestamp":1773010551000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Left ventricular remodeling and diastolic dysfunction predict cognitive decline in older adults"],"prefix":"10.1002","volume":"22","author":[{"given":"Arshama","family":"Dehghan","sequence":"first","affiliation":[{"name":"Department of Internal Medicine UT Southwestern Medical Center  Dallas Texas 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