{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T02:49:11Z","timestamp":1787280551237,"version":"build-2736575974"},"reference-count":59,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T00:00:00Z","timestamp":1770249600000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp; Dementia"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Epigenetic assays may support non\u2010invasive dementia risk stratification; community views on willingness and implementation remain under\u2010characterized.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>In a survey of 425 adults \u226550 years old, we assessed the willingness for a hypothetical epigenetic test, implementation preferences, reactions to a high\u2010risk result, behavior\u2010change intentions, and reasons for not testing using multivariable models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Overall, 82.1% showed a willingness. Health literacy (odds ratio [OR]\u00a0=\u00a02.61) and Alzheimer's disease (AD) concern (OR\u00a0=\u00a02.06) increased that willingness; doctor dependence decreased it (OR\u00a0=\u00a00.62). The top drivers were perceived to be accuracy and speed. The preferred modality was a combination of biomarker and cognitive over biomarker\u2010only. Intended changes prioritized alcohol reduction, then diet, exercise, cognitive activity. Risk worry and insurance concerns exceeded stigma; higher literacy related to lower stigma, and epigenetics familiarity and AD worry related to higher insurance concern. The reasons for not testing were data privacy\/accuracy concerns, logistics\/costs, and needles.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Findings support emphasizing test accuracy, turnaround, and governance\/legal information when implementing DNAm testing for dementia risk.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71094","type":"journal-article","created":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T03:06:22Z","timestamp":1770347182000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Community perspectives on epigenetic dementia risk testing: Willingness, implementation preferences, and reasons for not testing in midlife and older adults"],"prefix":"10.1002","volume":"22","author":[{"given":"Deirdre M.","family":"O'Shea","sequence":"first","affiliation":[{"name":"Comprehensive Center for Brain Health Department of Neurology Miller School of Medicine University of Miami  Boca Raton Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devi","family":"Dhanekula","sequence":"additional","affiliation":[{"name":"Comprehensive Center for Brain Health Department of Neurology Miller School of Medicine University of Miami  Boca Raton Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swati","family":"Kumar","sequence":"additional","affiliation":[{"name":"Miller School of Medicine University of Miami  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lily","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Biostatistics Department of Public Health Sciences Miller School of Medicine University of Miami  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Wiese","sequence":"additional","affiliation":[{"name":"Christine E. Lynn College of Nursing Florida Atlantic University  Boca Raton Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatjana","family":"Rundek","sequence":"additional","affiliation":[{"name":"Department of Neurology and Evelyn F. 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