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Micro\u2010 and nanoplastics (MNPs) are widespread pollutants linked to neurotoxicity, but their role in AD remains unclear.<\/jats:p>\n <\/jats:sec>\n \n METHODS<\/jats:title>\n We investigated the effects of 90\u2010day intragastric exposure to polystyrene nanoplastics (PS\u2010NPs) in amyloid precursor protein\/presenilin 1 (APP\/PS1) mice using behavioral tests, brain imaging, histopathology, and cell\u2010type\u2010resolved proteomics.<\/jats:p>\n <\/jats:sec>\n \n RESULTS<\/jats:title>\n PS\u2010NPs exacerbated cognitive deficits and hippocampal damage in APP\/PS1 mice. Proteomic and CellChat analyses revealed PS\u2010NPs enhanced neuroglial communication through the collagen\u2013integrin axis. In vitro triculture demonstrated that PS\u2010NPs strengthened collagen\u2010mediated astrocyte\u2013microglia\u2013neuron signaling, whereas in vivo blockade with TC\u2010I 15 suppressed collagen activation and improved cognition in PS\u2010NP\u2010exposed APP\/PS1 mice. Single\u2010nucleus RNA sequencing of human AD brains validated conserved activation of collagen signaling.<\/jats:p>\n <\/jats:sec>\n \n DISCUSSION<\/jats:title>\n Our findings highlight that PS\u2010NPs exacerbate cognitive impairment in AD by driving collagen\u2010dependent neuroglial dysfunction, establishing MNPs as modifiable environmental risk factors.<\/jats:p>\n <\/jats:sec>\n \n Highlights<\/jats:title>\n \n \n \n MNPs act as environmental risk factors that worsen cognitive impairment in AD.<\/jats:p>\n <\/jats:list-item>\n \n PS\u2010NPs trigger glial\u2013neuronal communication via the collagen\u2013integrin axis in AD.<\/jats:p>\n <\/jats:list-item>\n \n PS\u2010NP\u2010induced astrocyte\u2010 and microglia\u2010derived collagen, driving neurotoxicity in AD.<\/jats:p>\n <\/jats:list-item>\n \n TC\u2010I 15 blocked collagen signaling and rescued cognition in PS\u2010NP\u2010exposed AD mice.<\/jats:p>\n <\/jats:list-item>\n \n Collagen signaling was upregulated in human AD brains, confirming disease relevance.<\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/alz.71096","type":"journal-article","created":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T04:56:06Z","timestamp":1769057766000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Nanoplastics trigger glial\u2013neuronal collagen signaling miscommunication to exacerbate cognitive impairment in Alzheimer's disease"],"prefix":"10.1002","volume":"22","author":[{"given":"Yizhou","family":"Zhong","sequence":"first","affiliation":[{"name":"National Medical Products Administration (NMPA) Key Laboratory for Safety Evaluation of Cosmetics Guangdong Provincial Key Laboratory of Tropical Disease Research Department of Toxicology School of Public Health Southern Medical University Guangzhou China"},{"name":"Department of Cardiovascular Surgery Zhujiang Hospital, Southern Medical University 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