{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T19:08:56Z","timestamp":1791486536633,"version":"4.3.4"},"reference-count":51,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T00:00:00Z","timestamp":1768867200000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp; Dementia"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Cognitive impairment among people with HIV (PWH) remains common, yet underlying mechanisms remain unclear. Alzheimer's disease (AD) is the leading cause of dementia, and blood\u2010based biomarkers offer a promising diagnostic alternative. We evaluated phosphorylated\u2010tau 217 (p\u2010tau217), neurofilament light (NfL), and glial fibrillary acidic protein (GFAP) as predictors of cognitive decline among virologically suppressed older PWH.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>Thai PWH aged \u226550 years with plasma viral loads\u00a0&lt;50 copies\/mL completed the Montreal Cognitive Assessment (MoCA) at baseline (2015\u20132017) and a follow\u2010up visit (2021\u20132024). Associations between each biomarker and cognitive trajectories were assessed using multivariate mixed\u2010effects models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Among 255 participants followed for a median of 5.9 years, those in Q4 of p\u2010tau217 and GFAP had greater MoCA decline than Q1\u20103 (p\u2010tau217: \u20103.3 vs. \u20101.4, p\u2010interaction\u00a0=\u00a00.02; GFAP: \u20102.9 vs. \u20101.3, p\u2010interaction\u00a0=\u00a00.03).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Elevated p\u2010tau217 and GFAP predict cognitive decline in PWH, underscoring AD and inflammatory biomarker relevance.<\/jats:p>\n                  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