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The apoptosis\u2010associated speck\u2010like protein containing a CARD (ASC), encoded by the\n                    <jats:italic>PYCARD<\/jats:italic>\n                    gene, plays a critical role in the formation of multiple inflammasomes, including NLRP3, a key mediator of inflammation signaling. Beyond its role in inflammasome formation, extracellular ASC specks have been shown to promote amyloid\u2010\u03b2 aggregation, showing a potential link between inflammation and plaque formation. 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