{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T10:02:01Z","timestamp":1780048921166,"version":"3.53.1"},"reference-count":15,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T00:00:00Z","timestamp":1772582400000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp; Dementia"],"published-print":{"date-parts":[[2026,3]]},"abstract":"Abstract<\/jats:title>\n \n INTRODUCTION<\/jats:title>\n The National Alzheimer's Coordinating Center (NACC) and Alzheimer's Disease Research Center (ADRC) Program advances dementia research by collecting and sharing standardized, longitudinal data, including the Uniform Data Set with the global research community. To modernize workflow and accelerate the availability of analyzable data, we co\u2010developed a consortium\u2010wide Electronic Data Capture and Submission system.<\/jats:p>\n <\/jats:sec>\n \n METHODS<\/jats:title>\n A cross\u2010disciplinary workgroup of ADRC and NACC members co\u2010developed the system using a stakeholder\u2010centered sociotechnical implementation model. Subgroups focused on requirements, development, and training. Surveys and pilot testing across centers guided design and priorities.<\/jats:p>\n <\/jats:sec>\n \n RESULTS<\/jats:title>\n Research Electronic Data Capture was selected as the foundational platform. Deliverables included modular UDS version 4 instruments, embedded logic and automated quality checks, dynamic training resources, and an API\u2010based submission pipeline to NACC. The platform was adopted across all 36 ADRCs and surveys indicated high user satisfaction.<\/jats:p>\n <\/jats:sec>\n \n DISCUSSION<\/jats:title>\n Beyond infrastructure, this initiative provides a scalable, stakeholder\u2010driven implementation model that supports higher\u2010quality, more timely multicenter data submission, accelerating\u00a0biomarker validation, early detection studies, and precision\u2010medicine analyses.<\/jats:p>\n <\/jats:sec>\n \n Highlights<\/jats:title>\n \n \n \n A cross\u2010disciplinary workgroup of ADRC and NACC members designed a stakeholder\u2010centric sociotechnical implementation model.<\/jats:p>\n <\/jats:list-item>\n \n The workgroup drove the adoption of a modernized data infrastructure across a national consortium.<\/jats:p>\n <\/jats:list-item>\n \n Deployed a modern electronic data capture and submission system for the ADRC program.<\/jats:p>\n <\/jats:list-item>\n \n Leveraged REDCap as a flexible, scalable tool for a large\u2010scale EDCS system.<\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/alz.71105","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T22:57:37Z","timestamp":1773010657000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A cross\u2010consortium, stakeholder\u2010driven model for implementing a modern electronic data capture and submission system across the Alzheimer's Disease Research Centers Program"],"prefix":"10.1002","volume":"22","author":[{"given":"Sarah","family":"Biber","sequence":"first","affiliation":[{"name":"Department of Neurology Washington University School of Medicine St. Louis Missouri USA"},{"name":"Institute for Informatics, Data Science & Biostatistics Washington University School of Medicine St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Gothard","sequence":"additional","affiliation":[{"name":"Oregon Alzheimer's Disease Research Center Oregon Health and Science University Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles F","family":"Murchison","sequence":"additional","affiliation":[{"name":"Birmingham Alzheimer's Disease Research Center University of Alabama Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"McLeod","sequence":"additional","affiliation":[{"name":"National Alzheimer's Coordinating Center University of Washington Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn","family":"Gauthreaux","sequence":"additional","affiliation":[{"name":"National Alzheimer's Coordinating Center University of Washington Seattle Washington 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USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan M.","family":"Reader","sequence":"additional","affiliation":[{"name":"Michigan Alzheimer's Disease Research Center University of Michigan Anna Arbor Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter","family":"Kukull","sequence":"additional","affiliation":[{"name":"Department of Neurology Washington University School of Medicine St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meredith","family":"Zozus","sequence":"additional","affiliation":[{"name":"South Texas Alzheimer's Disease Research Center University of Texas Health Science Center San Antonio Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudeshna","family":"Das","sequence":"additional","affiliation":[{"name":"Massachusetts Alzheimer Disease Research Center Massachusetts General Hospital Charlestown Massachusetts 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