{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T04:45:30Z","timestamp":1782535530179,"version":"3.54.5"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T00:00:00Z","timestamp":1772236800000},"content-version":"vor","delay-in-days":27,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Patient and public involvement and engagement (PPIE) improves research quality but is often limited in scale. This study explored the potential for large\u2010scale PPIE using a Web\u2010based approach.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>We created an online portal to gather public views on dementia research and a UK\u2010based adaptive platform trial testing repurposed Alzheimer's disease drugs. Participants ranked four anonymized drugs and completed discrete choice experiments on treatment trade\u2010offs. Analyses were stratified by sex, age, and dementia experience.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Among 3250 people across 27 countries (87.4% UK\u2010based), 79.6% expressed positive attitudes toward the trial. Metformin was the most preferred drug, followed by atomoxetine, isosorbide mononitrate, and levetiracetam. Probability of severe side effects was the most influential treatment attribute, followed by probability of mild side effects and type of evidence. Subgroup analyses supported the main findings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Web\u2010based PPIE can effectively inform dementia research at scale and provides a reusable resource for other studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71113","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T23:12:05Z","timestamp":1773011525000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Patient and public involvement and engagement in clinical trials at scale: Analysis of the first 3250 responses on the POrtal for Patient and Public Engagement in Dementia (POPPED)"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5201-9905","authenticated-orcid":false,"given":"Hongyi","family":"Qin","sequence":"first","affiliation":[{"name":"Department of Public Information Resources Management Zhejiang University  Hangzhou China"},{"name":"Department of Psychiatry University of Cambridge  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Pointon","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Cambridge  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Carpenter","sequence":"additional","affiliation":[{"name":"MRC Clinical Trials Unit University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Raymont","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Oxford  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ross","family":"Dunne","sequence":"additional","affiliation":[{"name":"Department of old age psychiatry Greater Manchester Mental Health NHS Foundation Trust Manchester UK"},{"name":"Department of psychiatry University of Manchester Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne","family":"Reeves","sequence":"additional","affiliation":[{"name":"Department of old age psychiatry University College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shabinah","family":"Ali","sequence":"additional","affiliation":[{"name":"MRC Clinical Trials Unit University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabahat","family":"Iqbal","sequence":"additional","affiliation":[{"name":"Department of neurology Imperial College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Bonet\u2010Olivares","sequence":"additional","affiliation":[{"name":"Department of neurology Imperial College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne","family":"Whittle","sequence":"additional","affiliation":[{"name":"MRC Clinical Trials Unit University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Rizzo","sequence":"additional","affiliation":[{"name":"Department of neurology Imperial College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paresh","family":"Malhotra","sequence":"additional","affiliation":[{"name":"UK Dementia Research Institute Care Research and Technology Centre Imperial College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin R","family":"Underwood","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Cambridge  Cambridge UK"},{"name":"Cambridgeshire and Peterborough NHS Trust  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the AD\u2010SMART team","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,28]]},"reference":[{"key":"e_1_2_8_2_1","volume-title":"Briefing Notes For Researchers\u2014Public Involvement in NHS, Health and Social Care Research","author":"National Institute for Health and Care Research","year":"2024"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-023-02445-x"},{"key":"e_1_2_8_4_1","volume-title":"Chief Scientist Office, Heath and Care Research Wales, Public Health Agency","author":"National Institute for Health and Care Research","year":"2025"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/d41573-023-00031-x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.j3453"},{"key":"e_1_2_8_7_1","unstructured":"National Institute for Health and Care Research.Guidance for applicants on working with people and communities.2024. Accessed August 4 2025.https:\/\/www.nihr.ac.uk\/research\u2010funding\/application\u2010support\/working\u2010with\u2010people\u2010and\u2010communities#:~:text=To%20help%20assess%20the%20impact%20of%20partnerships (PiiAF)%20has%20been%20produced%20to%20help%20researchers"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1369-7625.2011.00695.x"},{"key":"e_1_2_8_9_1","volume-title":"Involving People From Diverse and Under\u2010Represented Groups","author":"University of Oxford"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.325.7375.1263"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-020-01544-7"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40900-025-00727-x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/pul2.70130"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.2316"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clon.2017.10.004"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awac169"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2022.7966"},{"key":"e_1_2_8_18_1","unstructured":"National Institute for Health and Care Research.PREliminary development of a Multi\u2010Arm multi\u2010Stage Trial platfOrm for Dementia and mild cOgNitive impairment due to Alzheimer's Disease (PRE\u2010MASTODON\u2010AD).2024. Accessed August 6 2025.https:\/\/www.dev.fundingawards.nihr.ac.uk\/award\/NIHR165710"},{"key":"e_1_2_8_19_1","unstructured":"University of Cambridge.POrtal for Patient and Public Engagement in Dementia research.2025. Accessed August 6 2025.https:\/\/popped.org.uk\/"},{"key":"e_1_2_8_20_1","unstructured":"University of Cambridge.AD\u2010SMART Survey.2025. 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