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Examining genetic variants that occur at higher frequency in India compared to other ancestries (i.e., Indian enriched variants) may identify genetic associations with cognitive function that are potentially unique to the Indian population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>We examined whether 3.43\u00a0million variants enriched in India compared to European (EA), East Asian (EAS), and African (AFR) ancestries were associated with seven measures of cognitive function in 2680 older adults from the Harmonized Diagnostic Assessment of Dementia for the Longitudinal Aging Study in India (LASI\u2010DAD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Identified Indian\u2010enriched variants were largely near loci previously associated with neuropsychiatric traits, N\u2010acetyltaurine levels, educational attainment, and cardiovascular risk factors for dementia. Several variants near genes previously associated with intellectual disabilities and synaptic function exhibited sex\u2010specific effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Indian\u2010enriched variants may play a significant role in cognitive function in South Asians living in India.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Some cognitive function\u2013associated variants are unique to, or more common in, India.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Implicated genes were in cardiovascular, neurocognitive, and inflammatory pathways.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Some Indian\u2010enriched genetic variants demonstrate\u00a0sex\u2010specific effects.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71115","type":"journal-article","created":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T05:36:39Z","timestamp":1769751399000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Indian\u2010enriched genetic variants are associated with cognitive function"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2065-9462","authenticated-orcid":false,"given":"Hasan","family":"Abu\u2010Amara","sequence":"first","affiliation":[{"name":"Department of Epidemiology School of Public Health, University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Epidemiology School of Public Health, University of Michigan  Ann Arbor Michigan USA"},{"name":"Survey Research Center Institute for Social Research, University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Biostatistics School of Public Health, University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuk Yee","family":"Leung","sequence":"additional","affiliation":[{"name":"Penn Neurodegeneration Genomics Center Department of Pathology and Laboratory Medicine Perelman School of Medicine, University of Pennsylvania  Philadelphia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard D.","family":"Schellenberg","sequence":"additional","affiliation":[{"name":"Penn Neurodegeneration Genomics Center Department of Pathology and Laboratory Medicine Perelman School of Medicine, University of Pennsylvania  Philadelphia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li\u2010San","family":"Wang","sequence":"additional","affiliation":[{"name":"Penn Neurodegeneration Genomics Center Department of Pathology and Laboratory Medicine Perelman School of Medicine, University of Pennsylvania  Philadelphia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aparajit B.","family":"Dey","sequence":"additional","affiliation":[{"name":"Department of Geriatric Medicine All India Institute of Medical Sciences  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharmistha","family":"Dey","sequence":"additional","affiliation":[{"name":"Department of Biophysics All India Institute of Medical Sciences  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Biostatistics School of Public Health, University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alden L.","family":"Gross","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinkook","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Economics University of Southern California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon L. 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