{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T19:10:59Z","timestamp":1788462659987,"version":"build-2803163510"},"reference-count":65,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T00:00:00Z","timestamp":1768953600000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100005753","name":"Kungliga Fysiografiska S\u00e4llskapet i Lund","doi-asserted-by":"publisher","award":["F2023\/2391"],"award-info":[{"award-number":["F2023\/2391"]}],"id":[{"id":"10.13039\/501100005753","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006075","name":"Greta och Johan Kocks stiftelser","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006075","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003792","name":"Hj\u00e4rnfonden","doi-asserted-by":"publisher","award":["FO2023\u20100259"],"award-info":[{"award-number":["FO2023\u20100259"]}],"id":[{"id":"10.13039\/501100003792","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003792","name":"Hj\u00e4rnfonden","doi-asserted-by":"publisher","award":["FO2024\u20100406"],"award-info":[{"award-number":["FO2024\u20100406"]}],"id":[{"id":"10.13039\/501100003792","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008599","name":"Alzheimerfonden","doi-asserted-by":"publisher","award":["AF\u2010994323"],"award-info":[{"award-number":["AF\u2010994323"]}],"id":[{"id":"10.13039\/501100008599","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008599","name":"Alzheimerfonden","doi-asserted-by":"publisher","award":["AF\u2010980901"],"award-info":[{"award-number":["AF\u2010980901"]}],"id":[{"id":"10.13039\/501100008599","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008599","name":"Alzheimerfonden","doi-asserted-by":"publisher","award":["and AF\u20101011956"],"award-info":[{"award-number":["and AF\u20101011956"]}],"id":[{"id":"10.13039\/501100008599","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["2023\u201002630"],"award-info":[{"award-number":["2023\u201002630"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp; Dementia"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Amyloid beta (A\u03b2) antibodies are the only therapies to slow cognitive decline in Alzheimer's disease (AD). Yet the sites where antibodies engage A\u03b2 in the brain and mechanisms that lower A\u03b2 are not fully understood. Defining A\u03b2 antibody localizations in the brain is essential to understand how immunotherapy is beneficial for AD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>N\u2010terminal A\u03b2 antibody 6E10 was injected via three different routes into different AD mouse models. N\u2010terminal A\u03b2 antibodies were empirically shown as most effective in AD mice. Antibody localization was examined in the brain after injections. Glymphatic dynamics were also evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>As expected, A\u03b2 antibody 6E10 bound to plaques but remarkably also localized to vulnerable neurons, such as hippocampal CA1 pyramidal cells, as well as microglia, astrocytes, oligodendrocytes, perivascular macrophages, and blood vessels. Antibodies did not alter glymphatic function.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>We provide detailed localizations of antibodies in AD mouse brains, offering insights into targets of A\u03b2 antibody\u2010based immunotherapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71121","type":"journal-article","created":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T04:58:28Z","timestamp":1769057908000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A\u03b2 antibodies target not only amyloid plaques but also distinct brain cells and vessels"],"prefix":"10.1002","volume":"22","author":[{"given":"Gehua","family":"Wen","sequence":"first","affiliation":[{"name":"Department of Experimental Medical Science Experimental Dementia Research Unit Lund University  Lund Sweden"},{"name":"School of Forensic Medicine China Medical University  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nils","family":"Lindblom","sequence":"additional","affiliation":[{"name":"Department of Experimental Medical Science Experimental Dementia Research Unit Lund University  Lund Sweden"},{"name":"Clinical Memory Research Unit Lund University  Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoni","family":"Zhan","sequence":"additional","affiliation":[{"name":"School of Forensic Medicine China Medical University  Shenyang China"},{"name":"Department of Experimental Medical Science Neural Plasticity and Repair Unit Lund University  Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megg","family":"Garcia\u2010Ryde","sequence":"additional","affiliation":[{"name":"Department of Experimental Medical Science Experimental Dementia Research Unit Lund University  Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomas","family":"Deierborg","sequence":"additional","affiliation":[{"name":"Department of Experimental Medical Science Experimental Neuroinflammation Lab Lund University  Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asgeir","family":"Kobro\u2010Flatmoen","sequence":"additional","affiliation":[{"name":"Kavli Institute for Systems Neuroscience Norwegian University of Science and Technology  Trondheim Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5500-6325","authenticated-orcid":false,"given":"Gunnar K.","family":"Gouras","sequence":"additional","affiliation":[{"name":"Department of Experimental Medical Science Experimental Dementia Research Unit Lund University  Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,21]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2212948"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43587-025-00810-8"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0572-14.2014"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3383-10.2010"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201606210"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.12.056"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64700-1"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.5858\/2001-125-0489-IAAPDO"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.3109\/13506120208995241"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.2001.01082.x"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2016.05.012"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1914593117"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2004.12.007"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1202-06.2006"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(03)00434-3"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64463-X"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(01)01876-6"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-18-07873.2002"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-24-08532.2003"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn842"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2005.01.040"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)61075-2"},{"key":"e_1_2_11_24_1","unstructured":"ShugartJ After Immunotherapy Amyloid Clearance Comes Down to Microglial Moods. March 14 2025.https:\/\/www.alzforum.org\/news\/research\u2010news\/after\u2010immunotherapy\u2010amyloid\u2010clearance\u2010comes\u2010down\u2010microglial\u2010moods"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1234"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2011.155"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-019-0485-0"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M700373200"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13789"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2016.05.015"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2019.11.008"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2015.119"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-023-10122-3"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2023.106035"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(18)30318-1"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-05397-3"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics14070731"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-025-00836-x"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1705971"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2022.2909"},{"issue":"3","key":"e_1_2_11_41_1","first-page":"393","article-title":"Ponezumab in mild\u2010to\u2010moderate Alzheimer's disease: randomized phase II PET\u2010PIB study","volume":"3","author":"Landen JW","year":"2017","journal-title":"Alzheimers Dement"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1456-24.2024"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-09-03745.2003"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2021-09.2009"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3697"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI23269"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.4161\/mabs.25424"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-021-02345-9"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.120922"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI86950"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/78682"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1326-7-8"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-9781(02)00261-9"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-008-0366-2"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-023-00649-w"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5167-03.2004"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-230349"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2005.05.022"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-010-0679-9"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2022.12.021"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-024-00759-z"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-024-01730-3"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20231363"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2022.08.010"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awae345"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-231238"}],"container-title":["Alzheimer's &amp; Dementia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.71121","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/alz.71121","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.71121","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T11:11:18Z","timestamp":1785928278000},"score":1,"resource":{"primary":{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1002\/alz.71121"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":65,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1002\/alz.71121"],"URL":"https:\/\/doi.org\/10.1002\/alz.71121","archive":["Portico"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2025.09.24.678300","asserted-by":"object"}]},"ISSN":["1552-5260","1552-5279"],"issn-type":[{"value":"1552-5260","type":"print"},{"value":"1552-5279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-10-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71121"}}