{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T07:16:29Z","timestamp":1783322189975,"version":"3.54.6"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T00:00:00Z","timestamp":1775433600000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["26K02729"],"award-info":[{"award-number":["26K02729"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["24K20522"],"award-info":[{"award-number":["24K20522"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["17H06286"],"award-info":[{"award-number":["17H06286"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Sleep quality critically influences amyloid beta (A\u03b2) clearance, yet the specific role of morning wake transition duration remains unexplored.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>This hypothesis\u2010driven secondary analysis examined 97 cognitively unimpaired older adults (mean age \u00b1 SD: 74.4\u00a0\u00b1\u00a05.8 years) who underwent 14\u2010day actigraphy and 18F\u2010florbetapir positron emission tomography (PET). Cognitive function was evaluated using the National Center for Geriatrics and Gerontology\u2010Functional Assessment Tool (NCGG\u2010FAT). Time to wake up (TWU) was calculated as the midpoint between initial wake and final rise times.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Binomial logistic regression models adjusted for age, depression, and sleep duration showed that extended TWU (&gt;6.23\u00a0min) associated with higher A\u03b2 positivity (27.1%\u00a0vs 10.2%, odds ratio [OR]\u00a0=\u00a01.85, 95% confidence interval [CI]: 1.11\u20133.07,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.019) and impaired word memory (OR\u00a0=\u00a02.17, 95% CI: 1.11\u20104.24,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.023). Exploratory analyses of additional cognitive domains showed no significant associations.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Prolonged morning wake transitions may represent a behavioral marker associated with A\u03b2 accumulation and memory impairment. The cross\u2010sectional design and modest sample size warrant cautious interpretation and replication in larger longitudinal cohorts.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71123","type":"journal-article","created":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T05:56:38Z","timestamp":1775541398000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prolonged morning wake transitions associated with amyloid beta burden: A cross\u2010sectional pilot study"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4064-5228","authenticated-orcid":false,"given":"Georg","family":"von Fingerhut","sequence":"first","affiliation":[{"name":"Department of Frailty Research Center for Gerontology and Social Science, National Center for Geriatrics and Gerontology  Obu Aichi 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