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Antibody characterization was conducted using Western blots and densitometry to assess the relative protein abundances of NRN1 in rodents, humans, and cell models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>NRN1 has a TREAT\u2010AD target risk score of 3.29 out of 5. Based on single\u2010nucleus RNA sequencing from SEA\u2010AD, NRN1 expression in excitatory neurons tends to decrease with increasing donor pseudo\u2010progression. Abcam ab64186 polyclonal NRN1 antibody detects NRN1 protein in vitro and in vivo at molecular weights that suggest NRN1 forms a homodimer. NRN1 protein abundance is comparable among controls and primary tauopathy cases, as well as Tau P301S mice and non\u2010transgenic littermates at 3 and 9 months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>These findings advance the investigation of NRN1 as a therapeutic candidate for AD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71149","type":"journal-article","created":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T09:32:18Z","timestamp":1770370338000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["NRN1 as a therapeutic target for Alzheimer's disease"],"prefix":"10.1002","volume":"22","author":[{"given":"Derian A.","family":"Pugh","sequence":"first","affiliation":[{"name":"Department of Neurology, Killion Center for Neurodegeneration and Experimental Therapeutics University of Alabama at Birmingham School of Medicine  Birmingham USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory A.","family":"Cary","sequence":"additional","affiliation":[{"name":"The Jackson Laboratory  Bar Harbor ME USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelsey M.","family":"Greathouse","sequence":"additional","affiliation":[{"name":"Department of Neurology, Killion Center for Neurodegeneration and Experimental Therapeutics University of Alabama at Birmingham School of Medicine  Birmingham USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren C.","family":"Nassour\u2010Caswell","sequence":"additional","affiliation":[{"name":"Department of Neurology, Killion Center for Neurodegeneration and Experimental Therapeutics University of Alabama at Birmingham School of Medicine  Birmingham USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma L.","family":"Hobby","sequence":"additional","affiliation":[{"name":"Department of Neurology, Killion Center for Neurodegeneration and Experimental Therapeutics University of Alabama at Birmingham School of Medicine  Birmingham USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas T.","family":"Seyfried","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Emory Goizueta Alzheimer's Disease Research Center Emory University School of Medicine  Atlanta USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy H.","family":"Herskowitz","sequence":"additional","affiliation":[{"name":"Department of Neurology, Killion Center for Neurodegeneration and Experimental Therapeutics University of Alabama at Birmingham School of Medicine  Birmingham 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