{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T03:54:28Z","timestamp":1792295668478,"version":"4.4.0"},"reference-count":51,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>This study evaluated the efficacy of deep cervical lymphatic\u2013venous anastomosis (dcLVA) for severe Alzheimer's disease (AD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>A total of 139 severe AD patients undergoing dcLVA were enrolled, and changes in cognitive function and biomarkers were evaluated by comparing preoperative measures with postoperative outcomes over a 6\u2010month follow\u2010up period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Patients undergoing dcLVA showed modestly elevated Mini\u2010Mental State Examination (MMSE) scores from 48\u00a0hour postoperatively to 6\u2010month follow\u2010up. At 6\u2010month, observable changes across functional status and neuropsychiatric symptoms were documented, as demonstrated by reductions in scores on the Activities of Daily Living (ADL) scale, Neuropsychiatric Inventory (NPI), Neuropsychiatric Inventory\u2010Caregiver Distress (NPI\u2010D), and Sleep Disorders Inventory (SDI). Biomarker analyses revealed decreased cerebrospinal fluid (CSF) \u03b2\u2010amyloid (A\u03b2) 42, A\u03b240, and p\u2010Tau levels postoperatively, along with increased plasma concentrations of these markers. No deaths or serious procedure\u2010related adverse events occurred during 6\u2010month follow\u2010up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>These findings suggest that dcLVA may confer multifaceted clinical benefits in severe AD patients, including attenuation of certain neuropsychiatric dysfunctions and a potential slowing of symptom progression.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71150","type":"journal-article","created":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T08:25:14Z","timestamp":1770107114000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Deep cervical lymphatic\u2013venous anastomosis attenuates cognitive dysfunction and biomarker abnormalities in severe Alzheimer's disease: A prospective single\u2010arm study"],"prefix":"10.1002","volume":"22","author":[{"given":"Xiaohong","family":"Fu","sequence":"first","affiliation":[{"name":"Department of Neurosurgery The Third Affiliated Hospital of Zunyi Medical University (The First People's Hospital of Zunyi)  Zunyi Guizhou Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology The Third Affiliated Hospital of Zunyi Medical University (The First People's Hospital of Zunyi)  Zunyi Guizhou Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuxia","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology The Third Affiliated Hospital of Zunyi Medical University (The First People's Hospital of Zunyi)  Zunyi Guizhou Province 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Third Affiliated Hospital of Zunyi Medical University (The First People's Hospital of Zunyi)  Zunyi Guizhou Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery The Third Affiliated Hospital of Zunyi Medical University (The First People's Hospital of Zunyi)  Zunyi Guizhou Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pan","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of TCM The Third Affiliated Hospital of Zunyi Medical University (The First People's Hospital of Zunyi)  Zunyi Guizhou Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaojian","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery The Third Affiliated Hospital of Zunyi Medical University (The First People's Hospital of Zunyi)  Zunyi Guizhou Province 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