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Survival in DS after AD diagnosis appears shorter than in sporadic AD; however, the factors influencing survival remain poorly understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>We analyzed 157 adults with DS from Spain and Ireland who died of AD between 2012 and 2024. Clinical, genetic, and care predictors were examined using Kaplan\u2013Meier curves and Cox regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Mean survival after AD diagnosis was 4.8 years (SD 3.5). Those in specialist intellectual disability dementia care had a longer survival time (mean 9.5 years) than other settings (mean 3.4 to 4.1 years;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001). Late\u2010onset myoclonic epilepsy in DS (LOMEDS) was linked to a threefold higher risk of death after onset (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Specialist care settings and LOMEDS timing significantly shape survival in DS\u2010associated AD, highlighting the importance of tailored services and proactive epilepsy treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71156","type":"journal-article","created":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T08:30:22Z","timestamp":1771317022000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Factors impacting survival in individuals with Down syndrome\u2010associated Alzheimer's 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