{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T08:57:10Z","timestamp":1785920230390,"version":"3.56.0"},"reference-count":48,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T00:00:00Z","timestamp":1773446400000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000867","name":"Robert Wood Johnson Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000867","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>The convergence of climate change, adverse environmental exposures, and rapid population aging necessitates an equity\u2010based paradigm shift in safeguarding brain health across the life course. Older adults, especially those in marginalized and low\u2010resource settings, face disproportionate exposure to air pollution, toxicants, and climate\u2010related hazards. Emerging evidence links these biophysical, social, and cultural vulnerabilities to cognitive decline and a heightened risk of developing Alzheimer's disease and related dementias (ADRDs), underscoring the need to examine cumulative exposures across the life course. Exposome\u2010informed research integrating magnetic resonance imaging biomarkers with socioenvironmental contexts remains limited in underrepresented populations but offers opportunities to detect subclinical markers of environmental harm and illuminate mechanistic pathways of ADRDs. Thus, future studies must adopt equity\u2010centered approaches, inclusive recruitment, and community\u2010driven interventions to address systemic inequities and cumulative exposures. Embedding environmental justice within neuroscience will advance preventative public health policies that mitigate inequities and protect brain health during climate change.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Marginalized communities remain underrepresented in brain health\/ Alzheimer's disease and related dementias (ADRDs) research.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Toxic environmental exposures worsen inequities in brain health across the life course.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Exposome\u2010informed neuroimaging may detect early neural markers of cognitive decline.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Future equity\u2010centered exposome\/neuroimaging work will inform brain health policy.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Need for life course interventions to mitigate environmental risk factors of ADRDs.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71158","type":"journal-article","created":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T10:26:20Z","timestamp":1773483980000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["From cradle to cortex: An exposome\u2010 and equity\u2010centered perspective of neurocognitive aging and dementia risk in the era of climate change"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8637-4729","authenticated-orcid":false,"given":"Kelly E.","family":"Perry","sequence":"first","affiliation":[{"name":"Nicholas School of the Environment Duke University  Durham USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1631-1340","authenticated-orcid":false,"given":"Jenna","family":"Merenstein","sequence":"additional","affiliation":[{"name":"Department of Psychology University of Utah  Salt Lake City USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,14]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-2667(21)00249-8"},{"key":"e_1_2_8_3_1","unstructured":"United Nations Department of Economic and Social Affairs. 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