{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T23:30:13Z","timestamp":1790983813658,"version":"4.1.0"},"reference-count":72,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T00:00:00Z","timestamp":1769731200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T00:00:00Z","timestamp":1769731200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000070","name":"National Institute of Biomedical Imaging and Bioengineering","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000070","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009804","name":"Northern California Institute for Research and Education","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009804","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","award":["LDRFP\u201021\u2010818464"],"award-info":[{"award-number":["LDRFP\u201021\u2010818464"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's & Dementia"],"published-print":{"date-parts":[[2026,2]]},"abstract":"\n INTRODUCTION<\/jats:title>\n Recent work has identified unique cognitive profiles for early\u2010onset Alzheimer's disease (EOAD) relative to late\u2010onset Alzheimer's disease (LOAD), however, examination has been limited in determining whether the association between age and cognitive severity at presentation also differs across conditions.<\/jats:p>\n <\/jats:sec>\n \n METHODS<\/jats:title>\n \n A series of\n linear spline regression<\/jats:italic>\n models was conducted across baseline cognitive data from 325 EOAD and 314 LOAD participants, after accounting for education, sex, and\n apolipoprotein<\/jats:italic>\n \u03b54 status.\n <\/jats:p>\n <\/jats:sec>\n \n RESULTS<\/jats:title>\n Significant differences existed in the relationship between baseline age and cognitive performance between EOAD and LOAD samples for Processing Speed\/Attention, Executive Functioning, and Episodic Immediate Memory. Younger participants from both EOAD and LOAD groups performed disproportionately worse on non\u2010amnestic cognitive domains, with this occurring to a greater extent in EOAD than LOAD.<\/jats:p>\n <\/jats:sec>\n \n DISCUSSION<\/jats:title>\n In the age of disease\u2010modifying treatments, results highlight the importance of assessing for cognitive declines in individuals starting much earlier than age 65.<\/jats:p>\n <\/jats:sec>\n \n Highlights<\/jats:title>\n \n \n \n Early\u2010onset Alzheimer's disease (EOAD) and late\u2010onset Alzheimer's disease (LOAD) participants each displayed cognitive impairments relative to same\u2010aged peers across most domains.<\/jats:p>\n <\/jats:list-item>\n \n Both groups displayed positive relationships between impairment among non\u2010amnestic cognitive domains and baseline age.<\/jats:p>\n <\/jats:list-item>\n \n This relationship displayed a significantly greater effect in EOAD than LOAD, with domains of Processing Speed\/Attention and Executive Functioning skills being the most pronounced.<\/jats:p>\n <\/jats:list-item>\n \n Of those participants developing AD, age displayed a disproportionate impact on their symptom onset.<\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/alz.71160","type":"journal-article","created":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T10:07:14Z","timestamp":1769767634000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Relationship between age and severity of cognitive impairment at diagnosis for early\u2010onset and late\u2010onset Alzheimer's disease: Comparison of LEADS and ADNI"],"prefix":"10.1002","volume":"22","author":[{"given":"Dustin B.","family":"Hammers","sequence":"first","affiliation":[{"name":"Department of Neurology Indiana University School of Medicine Indianapolis Indiana 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