{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:36:01Z","timestamp":1792787761527,"version":"4.5.0"},"reference-count":56,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T00:00:00Z","timestamp":1770768000000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["GA16788"],"award-info":[{"award-number":["GA16788"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01\u2010AG058676\u201001A1"],"award-info":[{"award-number":["R01\u2010AG058676\u201001A1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's & Dementia"],"published-print":{"date-parts":[[2026,2]]},"abstract":"Abstract<\/jats:title>\n \n INTRODUCTION<\/jats:title>\n The Centiloid scale is the standard for amyloid (A\u03b2) PET quantification in research and clinical settings. However, variability between tracers and scanners remains a challenge.<\/jats:p>\n <\/jats:sec>\n \n METHODS<\/jats:title>\n This study introduces DeepSUVR, a deep learning method to correct Centiloid quantification, by penalizing implausible longitudinal trajectories during training. The model was trained using data from 2,129 participants (7,149 A\u03b2 positron emission tomography [PET] scans) in the Australian Imaging, Biomarkers and Lifestyle Study of ageing (AIBL)\/Alzheimer's Disease Neuroimaging Initiative (ADNI) and validated using 15,807 A\u03b2 PET scans from 10,543 participants across 10 external datasets.<\/jats:p>\n <\/jats:sec>\n \n RESULTS<\/jats:title>\n DeepSUVR increased correlation between tracers, and reduced variability in the A\u00df\u2010negatives. It showed significantly stronger association with cognition, visual reads, neuropathology, and increased longitudinal consistency between studies. DeepSUVR also increased the effect size for detecting small treatment related slowing of amyloid accumulation in the A4 study.<\/jats:p>\n <\/jats:sec>\n \n DISCUSSION<\/jats:title>\n DeepSUVR substantially advances A\u03b2 PET quantification, outperforming all standard approaches, which is particularly important for clinical decision making and to detect subtle or early changes in A\u03b2.<\/jats:p>\n <\/jats:sec>\n \n Highlights<\/jats:title>\n \n \n \n Novel artificial intelligence (AI)\u2010method that penalizes biologically implausible longitudinal trajectories, enabling the model to learn standardized uptake value ratios (SUVR) correction factors without requiring longitudinal data at inference time.<\/jats:p>\n <\/jats:list-item>\n \n Improves Centiloid consistency across tracers and studies, significantly enhancing cross\u2010sectional and longitudinal amyloid positron emission tomography (PET) quantification.<\/jats:p>\n <\/jats:list-item>\n \n DeepSUVR\u2010derived Centiloids show stronger associations with cognition, visual reads, and neuropathology.<\/jats:p>\n <\/jats:list-item>\n \n Longitudinal variability is reduced three\u2010 to five\u2010fold, enabling more reliable tracking of amyloid accumulation and better detection of treatment effects.<\/jats:p>\n <\/jats:list-item>\n \n Novel reference and target masks derived from DeepSUVR replicate most of the model's performance, offering a practical alternative for integration into existing pipelines.<\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/alz.71162","type":"journal-article","created":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T12:31:16Z","timestamp":1770813076000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["AI\u2010enhanced Centiloid quantification of amyloid PET 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