{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T22:14:33Z","timestamp":1782944073915,"version":"3.54.5"},"reference-count":43,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T00:00:00Z","timestamp":1769731200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T00:00:00Z","timestamp":1769731200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U54AG065181"],"award-info":[{"award-number":["U54AG065181"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp; Dementia"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      Alzheimer's disease (AD) research has entered a new era where public\u2010private partnerships are reigniting the pursuit of disease\u2010modifying therapies targeting mechanisms beyond amyloid and tau. This perspective outlines how Monument Biosciences was founded to advance novel therapies by translating National Institutes of Health (NIH) \u2010supported discoveries from the TaRget Enablement to Accelerate Therapy Development for AD (TREAT\u2010AD) and the Model Organism Development and Evaluation for Late\u2010onset AD (MODEL\u2010AD) consortia into a venture\u2010backed pipeline focused on neuroinflammation. Monument Bio strategically builds on genetic validation and high\u2010quality, nondilutive\u2010funded research and serves as a case study in how academic research can reduce risk in early\u2010stage biotech development to advance novel therapies. The company exemplifies a novel academic\u2010startup collaboration model, emphasizing robust biomarker strategies to streamline clinical development. Aligned with the framework presented by Richardson\n                      <jats:italic>et\u00a0al.<\/jats:italic>\n                      , in this issue, this approach supports a new generation of neuroscience companies grounded in open science, strong target validation, and disease\u2010relevant endpoints.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>The Alzheimer's field is poised for next\u2010generation therapies beyond amyloid and tau.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Monument Bio translates National Institutes of Health (NIH)\u2010supported science into a venture\u2010backed Alzheimer's pipeline.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>TaRget Enablement to Accelerate Therapy Development for AD (TREAT\u2010AD) and Model Organism Development and Evaluation for Late\u2010onset AD (MODEL\u2010AD) de\u2010risk programs with validated assays, probes, and biomarker tools.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Monument Bio shows how TREAT\u2010AD's Target Enabling Packages (TEPs) enable difficult targets.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Integrated biomarkers enable predictive translation, faster approval, and investment rationale.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71165","type":"journal-article","created":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T04:37:57Z","timestamp":1769834277000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["From consortia discovery to biotech creation: An innovative approach to next\u2010gen Alzheimer's drugs"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8879-9384","authenticated-orcid":false,"given":"Sarah F.","family":"Giardina","sequence":"first","affiliation":[{"name":"Monument Biosciences  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Culver","sequence":"additional","affiliation":[{"name":"Monument Biosciences  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chandrama","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Monument Biosciences  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Mirescu","sequence":"additional","affiliation":[{"name":"Monument Biosciences  Indianapolis Indiana USA"},{"name":"Indiana Biosciences Research Institute  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian L.","family":"Oblak","sequence":"additional","affiliation":[{"name":"Monument Biosciences  Indianapolis Indiana USA"},{"name":"Stark Neuroscience Research Institute Indiana University School of Medicine  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jared","family":"Brosch","sequence":"additional","affiliation":[{"name":"Monument Biosciences  Indianapolis Indiana USA"},{"name":"Department of Neurology Indiana University School of Medicine  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. Brent","family":"Clayton","sequence":"additional","affiliation":[{"name":"Monument Biosciences  Indianapolis Indiana USA"},{"name":"Department of Medicine Division of Clinical Pharmacology Indiana University School of Medicine  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey L.","family":"Dage","sequence":"additional","affiliation":[{"name":"Monument Biosciences  Indianapolis Indiana USA"},{"name":"Indiana Biosciences Research Institute  Indianapolis Indiana USA"},{"name":"Department of Neurology Indiana University School of Medicine  Indianapolis Indiana USA"},{"name":"Department of Medicine Division of Clinical Pharmacology Indiana University School of Medicine  Indianapolis Indiana USA"},{"name":"Stark Neuroscience Research Institute Indiana University School of Medicine  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce T.","family":"Lamb","sequence":"additional","affiliation":[{"name":"Monument Biosciences  Indianapolis Indiana USA"},{"name":"Department of Medicine Division of Clinical Pharmacology Indiana University School of Medicine  Indianapolis Indiana USA"},{"name":"Stark Neuroscience Research Institute Indiana University School of Medicine  Indianapolis Indiana USA"},{"name":"Department of Medical and Molecular Genetics Indiana University School of Medicine  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy I.","family":"Richardson","sequence":"additional","affiliation":[{"name":"Monument Biosciences  Indianapolis Indiana USA"},{"name":"Indiana Biosciences Research Institute  Indianapolis Indiana USA"},{"name":"Department of Medicine Division of Clinical Pharmacology Indiana University School of Medicine  Indianapolis Indiana USA"},{"name":"Stark Neuroscience Research Institute Indiana University School of Medicine  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derek","family":"Small","sequence":"additional","affiliation":[{"name":"Monument Biosciences  Indianapolis Indiana USA"},{"name":"Luson Bioventures  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan D.","family":"Palkowitz","sequence":"additional","affiliation":[{"name":"Monument Biosciences  Indianapolis Indiana USA"},{"name":"Indiana Biosciences Research Institute  Indianapolis Indiana USA"},{"name":"Department of Medicine Division of Clinical Pharmacology Indiana University School of Medicine  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,30]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.70235"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/MS9.0000000000002047"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz70964"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/trc2.12110"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/alzrt90"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.14105"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/cphg.105"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12849"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.14078"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2023.08.008"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13828"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13840"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2022.886575"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/164_2024_739"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10928\u2010023\u201009876\u20106"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12877"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2025.02.011"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2024.08.004"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2022.05.006"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2024.105322"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/978\u20103\u2010030\u201005542\u20104_2"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina58070952"},{"key":"e_1_2_6_24_1","unstructured":"FDA\u2010NIH Biomarker Working Group.BEST (Biomarkers EndpointS and other Tools) Resource [Internet].Silver Spring (MD): Food and Drug Administration (US).2016. 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