{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T12:46:50Z","timestamp":1785934010257,"version":"3.56.0"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T00:00:00Z","timestamp":1769040000000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100020132","name":"Medizinische Fakult\u00e4t Carl Gustav Carus, Technische Universit\u00e4t Dresden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100020132","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's & Dementia"],"published-print":{"date-parts":[[2026,1]]},"abstract":"Abstract<\/jats:title>\n \n INTRODUCTION<\/jats:title>\n The alpha\u2010synuclein seed amplification assay (SAA) has shown excellent performance in the detection of Lewy body pathology in cerebrospinal fluid (CSF). Lewy body pathology is prognostically relevant in patients at risk for dementia. Current assays only provide binary results, so there is a need to quantify the extent of pathology in living patients.<\/jats:p>\n <\/jats:sec>\n \n METHODS<\/jats:title>\n In addition to the \u201cstandard\u201d SAA, we developed a quantitative SAA (qnSAA) and measured 432 CSF samples (216 baseline\u2013follow\u2010up pairs).<\/jats:p>\n <\/jats:sec>\n \n RESULTS<\/jats:title>\n qnSAA results correlated with cognitive performance. Seventy\u2010five percent of participants with fast qnSAA kinetics converted to dementia in the observed interval. Overall, participants with fast qnSAA kinetics accounted for 27.3% of dementia converters in the entire cohort.<\/jats:p>\n <\/jats:sec>\n \n DISCUSSION<\/jats:title>\n Findings demonstrate promising properties of qnSAA measurements in a cohort of patients at risk for dementia. qnSAA results showed improved prognostic relevance and have potential to measure target engagement of therapies against Lewy body pathology.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/alz.71167","type":"journal-article","created":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T06:30:57Z","timestamp":1769149857000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Alpha\u2010synuclein quantitative seed amplification assay predicts conversion to dementia"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2449-5530","authenticated-orcid":false,"given":"Stefan","family":"Br\u00e4uer","sequence":"first","affiliation":[{"name":"Department of Neurology, Faculty of Medicine and University Hospital Carl Gustav Carus Technische Universit\u00e4t Dresden Dresden Germany"},{"name":"German Center for Neurodegenerative Diseases (DZNE) Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Verena","family":"Sondermann","sequence":"additional","affiliation":[{"name":"Department of Neurology, Faculty of Medicine and University Hospital Carl Gustav Carus Technische Universit\u00e4t Dresden Dresden Germany"},{"name":"German Center for Neurodegenerative Diseases (DZNE) Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I\u00f1aki","family":"Schniewind","sequence":"additional","affiliation":[{"name":"Department of Neurology, Faculty of Medicine and University Hospital Carl Gustav Carus Technische Universit\u00e4t Dresden Dresden Germany"},{"name":"German Center for Neurodegenerative Diseases (DZNE) Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"H\u00e4hnel","sequence":"additional","affiliation":[{"name":"Department of Neurology, Faculty of Medicine and University Hospital Carl Gustav Carus Technische Universit\u00e4t Dresden Dresden Germany"},{"name":"German Center for Neurodegenerative Diseases (DZNE) Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Dinter","sequence":"additional","affiliation":[{"name":"Department of Neurology, Faculty of Medicine and University Hospital Carl Gustav Carus Technische Universit\u00e4t Dresden Dresden Germany"},{"name":"German Center for Neurodegenerative Diseases (DZNE) Dresden 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