{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T05:40:57Z","timestamp":1783575657605,"version":"3.55.0"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,22]],"date-time":"2026-02-22T00:00:00Z","timestamp":1771718400000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271441"],"award-info":[{"award-number":["82271441"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82571604"],"award-info":[{"award-number":["82571604"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>White matter hyperintensities (WMHs) are common in both Alzheimer's disease (AD) and cerebral amyloid angiopathy (CAA), yet their spatial tissue characteristics and microstructural differences remain poorly understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>We analyzed 351 participants: 184 amyloid beta (A\u03b2)\u2010positive AD and mild cognitive impairment (MCI), 139 A\u03b2\u2010negative cognitively normal controls (CN), and 28 probable CAA. Multimodal magnetic resonance imaging metrics were used to estimate spatial gradient parameters for periventricular WMHs (pWMH) and deep WMHs (dWMH).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>CAA demonstrated distinctive free\u2010water fraction (FWF), fractional anisotropy (FA), mean diffusivity (MD), and plasma volume within pWMH, as well as spatial gradient parameters of pWMH. These pWMH spatial gradient parameters produced area under the curve (AUC) values of 0.71 (FWF), 0.72 (MD), and 0.79 (FA) when distinguishing CAA from AD\/MCI. We retested a subset of the cohort after 1 to 2 years (AUCs: FWF\u00a0=\u00a00.89, MD\u00a0=\u00a00.79, FA\u00a0=\u00a00.85).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Spatial gradient parameters reflect disease\u2010specific microstructural and vascular changes, providing insights into CAA and AD pathology.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71182","type":"journal-article","created":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T03:18:51Z","timestamp":1771816731000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Perilesional white matter gradients reveal microstructural differences in cerebral amyloid angiopathy versus Alzheimer's disease"],"prefix":"10.1002","volume":"22","author":[{"given":"Xinyuan","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Neurology &amp; Institute of Neurology Ruijin Hospital affiliated with Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junfang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine &amp; PET Center Huashan Hospital Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine &amp; PET Center Huashan Hospital Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingting","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Neurology &amp; Institute of Neurology Ruijin Hospital affiliated with Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine &amp; PET Center Huashan Hospital Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjing","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology &amp; Institute of Neurology Ruijin Hospital affiliated with Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Neurology &amp; Institute of Neurology Ruijin Hospital affiliated with Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihui","family":"Guan","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine &amp; PET Center Huashan Hospital Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurology &amp; Institute of Neurology Ruijin Hospital affiliated with Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulei","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Neurology &amp; Institute of Neurology Ruijin Hospital affiliated with Shanghai Jiao Tong University School of Medicine  Shanghai China"},{"name":"Clinical Neuroscience Center Ruijin Hospital LuWan Branch Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdy H.","family":"Selim","sequence":"additional","affiliation":[{"name":"Stroke Division Department of Neurology Beth Israel Deaconess Medical Center Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomeng","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Neurology &amp; 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