{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:22:02Z","timestamp":1788481322883,"version":"build-2803163510"},"reference-count":57,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T00:00:00Z","timestamp":1772150400000},"content-version":"vor","delay-in-days":26,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100007625","name":"Cure Alzheimer's Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007625","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007457","name":"JPB Foundation","doi-asserted-by":"publisher","award":["263201600085U"],"award-info":[{"award-number":["263201600085U"]}],"id":[{"id":"10.13039\/100007457","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["T32GM007748"],"award-info":[{"award-number":["T32GM007748"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Alzheimer's disease (AD) is the most common form of dementia. Studies have suggested prevalence is greater in individuals self\u2010identifying as Hispanic. Population\u2010specific results enable personalized and equitable interventions. Ethnicity as a stratifier co\u2010occurs with genomic inflation due to heterogeneity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>We conducted genome\u2010wide association studies (GWAS) and meta\u2010analyses among subjects from the Alzheimer's Disease Sequencing Project (ADSP) Umbrella whole genome sequencing (WGS) dataset who self\u2010identified as Hispanic and All of Us (AoU) sub\u2010cohorts matched to that cohort, using projected genetically\u2010derived principal components.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      We identified a common variant in\n                      <jats:italic>PIEZO2<\/jats:italic>\n                      on chromosome 18 protective for AD in ADSP subjects, with a\n                      <jats:italic>p<\/jats:italic>\n                      \u2010value just beyond genome\u2010wide significance (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0). Meta\u2010analyses with genetically\u2010matched AoU participants yielded three (two novel) genome\u2010wide significant AD\u2010associated loci based on rare lead variants: rs374043832 (\n                      <jats:italic>RGS6\/PSEN1<\/jats:italic>\n                      ), rs192423465 (\n                      <jats:italic>ASPSCR1<\/jats:italic>\n                      ), and rs935208076 (\n                      <jats:italic>GDAP2<\/jats:italic>\n                      ), which were nominally significant in AoU sub\u2010cohorts.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>We demonstrate a way to match subjects between large biobanks and small disease\u2010specific cohorts, enabling novel findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71189","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T11:22:53Z","timestamp":1772968973000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Matching heterogeneous cohorts by projected principal components reveals two novel Alzheimer's disease\u2010associated genes in the Hispanic population"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8103-0329","authenticated-orcid":false,"given":"Julian Daniel Sunday","family":"Willett","sequence":"first","affiliation":[{"name":"Genetics and Aging Unit and McCance Center for Brain Health Department of Neurology Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamad","family":"Waqas","sequence":"additional","affiliation":[{"name":"Genetics and Aging Unit and McCance Center for Brain Health Department of Neurology Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serhiy","family":"Naumenko","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Harvard T.H. Chan School of Public Health  Boston Massachusetts USA"},{"name":"Newborn Screening Ontario  Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina","family":"Mullin","sequence":"additional","affiliation":[{"name":"Genetics and Aging Unit and McCance Center for Brain Health Department of Neurology Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian","family":"Hecker","sequence":"additional","affiliation":[{"name":"Channing Division of Network Medicine Brigham and Women's Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Bertram","sequence":"additional","affiliation":[{"name":"L\u00fcbeck Interdisciplinary Platform for Genome Analytics, Institutes of Neurogenetics and Cardiogenetics University of L\u00fcbeck  L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Lange","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Harvard T.H. Chan School of Public Health  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioannis","family":"Vlachos","sequence":"additional","affiliation":[{"name":"Department of Pathology Beth Israel Deaconess Medical Center  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Winston","family":"Hide","sequence":"additional","affiliation":[{"name":"Department of Pathology Beth Israel Deaconess Medical Center  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rudolph E.","family":"Tanzi","sequence":"additional","affiliation":[{"name":"Genetics and Aging Unit and McCance Center for Brain Health Department of Neurology Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dmitry","family":"Prokopenko","sequence":"additional","affiliation":[{"name":"Genetics and Aging Unit and McCance Center for Brain Health 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