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<jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Automated cerebrospinal fluid (CSF) biomarker assays have largely replaced manual immunoassays for measuring amyloid pathology in CSF. We refitted and validated the ABIDE model, predicting progression from mild cognitive impairment (MCI) to dementia, with CSF measurements from the automated Elecsys platform.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>We included 2413 MCI participants (998 [41%] amyloid\u2010positive) from seven observational cohorts. Elecsys was used in 958 (40%) participants. The parameters of the previous ABIDE Cox model were re\u2010estimated. Model discrimination and calibration were evaluated with leave\u2010one\u2010cohort\u2010out cross\u2010validation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>During follow\u2010up, 1034 (42%; 585 [58%] amyloid\u2010positive) participants developed dementia. Discrimination was good with Harrell's C of 0.70 (95% confidence interval [CI]: 0.66\u20130.73). Calibration was good in the total population and amyloid\u2010positive subgroup, with substantial predicted progression risks for all amyloid\u2010positive participants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>We refitted the ABIDE model, predicting MCI to dementia progression, with automated CSF measurements. The model was well calibrated in amyloid\u2010positive patients and may support clinical discussions regarding ATTs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71192","type":"journal-article","created":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T09:50:42Z","timestamp":1770630642000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Revising the ABIDE MCI to dementia prediction model for automated cerebrospinal fluid assays"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1671-6850","authenticated-orcid":false,"given":"Pieter J.","family":"van der Veere","sequence":"first","affiliation":[{"name":"Amsterdam Neuroscience  Amsterdam The Netherlands"},{"name":"Alzheimer Center Amsterdam Department of Neurology Vrije Universiteit Amsterdam Amsterdam UMC location VUmc  Amsterdam the Netherlands"},{"name":"Department of Epidemiology and Data Science Amsterdam UMC  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Argonde C.","family":"van Harten","sequence":"additional","affiliation":[{"name":"Amsterdam Neuroscience  Amsterdam The Netherlands"},{"name":"Alzheimer Center Amsterdam Department of Neurology Vrije Universiteit Amsterdam Amsterdam UMC location VUmc  Amsterdam the Netherlands"},{"name":"Neurochemistry Laboratory Department of Laboratory Medicine Amsterdam Neuroscience Vrije Universiteit Amsterdam Amsterdam UMC  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid S.","family":"van Maurik","sequence":"additional","affiliation":[{"name":"Northwest Academy Northwest Clinics Alkmaar  Alkmaar The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte E.","family":"Teunissen","sequence":"additional","affiliation":[{"name":"Amsterdam Neuroscience  Amsterdam The Netherlands"},{"name":"Neurochemistry Laboratory Department of Laboratory Medicine Amsterdam Neuroscience Vrije Universiteit Amsterdam Amsterdam UMC  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederik","family":"Barkhof","sequence":"additional","affiliation":[{"name":"Amsterdam Neuroscience  Amsterdam The Netherlands"},{"name":"UCL Hawkes Institute Dept of Medical Physics University College London  London UK"},{"name":"Department of Radiology &amp; Nuclear Medicine Vrije Universiteit Amsterdam Amsterdam University Medical Center  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie J. B.","family":"Vos","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neuropsychology Maastricht University School for Mental Health and Neuroscience Alzheimer Centre Limburg  Maastricht Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lutz","family":"Froelich","sequence":"additional","affiliation":[{"name":"Department of Geriatric Psychiatry Zentralinstitut f\u00fcr Seelische Gesundheit Medical Faculty Mannheim University of Heidelberg  Mannheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Kornhuber","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy Friedrich\u2010Alexander University of Erlangen\u2010N\u00fcrnberg  Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Wiltfang","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy University Medical Center 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