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However, the value of sequential [\n 18<\/jats:sup>\n F]PI\u20102620 imaging for tracking tau accumulation during the disease course has not yet been investigated.\n <\/jats:p>\n <\/jats:sec>\n \n METHODS<\/jats:title>\n \n Twenty\u2010three PSP patients underwent two [\n 18<\/jats:sup>\n F]PI\u20102620 PET scans (interval: 21.4\u00a0\u00b1\u00a04.3 months) and were compared to cross\u2010sectional data from 25 healthy controls. Regional volume of distribution ratio values were analyzed for longitudinal tau changes, clinical correlations, and network\u2010based propagation.\n Post mortem<\/jats:italic>\n analyses examined neuronal density and AT8 tau pathology.\n <\/jats:p>\n <\/jats:sec>\n \n RESULTS<\/jats:title>\n \n Subcortical tau PET signals increased, strongest in the globus pallidus internus (\n P<\/jats:italic>\n \u00a0<\u00a00.0001). Patients with low baseline tau showed the largest increases. Despite clinical worsening (Progressive Supranuclear Palsy Rating Scale +48%), tau PET change did not correlate with symptom progression. Tau accumulation followed functional connectivity (\n R<\/jats:italic>\n \u00a0=\u00a00.34,\n P<\/jats:italic>\n \u00a0<\u00a00.0001).\n Post mortem<\/jats:italic>\n data linked elevated tau PET to higher AT8 burden despite neuronal loss.\n <\/jats:p>\n <\/jats:sec>\n \n DISCUSSION<\/jats:title>\n \n [\n 18<\/jats:sup>\n F]PI\u20102620 PET enables monitoring of tau progression in PSP, indicating network\u2010based tau propagation with saturation in advanced stages.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/alz.71195","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T22:21:20Z","timestamp":1773008480000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Longitudinal monitoring of tau aggregation in progressive supranuclear palsy with [\n 18<\/sup>\n F]PI\u20102620 PET"],"prefix":"10.1002","volume":"22","author":[{"given":"Johannes","family":"Gn\u00f6rich","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine LMU University Hospital LMU Munich Munich Germany"},{"name":"German Center for Neurodegenerative Diseases (DZNE) Munich Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Kusche\u2010Palenga","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine LMU University Hospital LMU Munich Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Palleis","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE) Munich Munich Germany"},{"name":"Department of Neurology LMU University Hospital LMU Munich Munich Germany"},{"name":"Munich Cluster for Systems Neurology (SyNergy) Munich 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Morgan Department of Radiology and Radiological Sciences Division of Nuclear Medicine Johns Hopkins School of Medicine Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikael","family":"Simons","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE) Munich Munich Germany"},{"name":"Munich Cluster for Systems Neurology (SyNergy) Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Levin","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE) Munich Munich Germany"},{"name":"Department of Neurology LMU University Hospital LMU Munich Munich Germany"},{"name":"Munich Cluster for Systems Neurology (SyNergy) Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jochen","family":"Herms","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE) Munich 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