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In a memory clinic sample, we investigated the relationship between memory\u2010related white matter pathways and OSA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      Eighty\u2010two participants (mean age 67.0) underwent neuropsychological testing and neuroimaging. Fixel\u2010based white matter analyses were conducted in the anterior thalamic radiation (ATR), cingulum, uncinate fasciculus (UF), and fornix. Oxygen desaturation index (ODI) from overnight polysomnography classified participants as controls (ODI\u00a0&lt;\u00a05,\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a026), mild OSA (ODI 5\u201314,\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a032), or moderate and severe OSA (ODI \u2265 15,\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a024).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>In mild OSA, white matter changes were seen in the ATR, UF, and fornix. In moderate and severe OSA, alterations were observed in the cingulum and fornix. Cingulum changes were linked to poorer verbal learning and memory.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>OSA is associated with disrupted memory\u2010related pathways. Cingulum changes are associated with memory performance in moderate and severe cases.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71197","type":"journal-article","created":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T09:49:32Z","timestamp":1770976172000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Microscopic white matter changes in the cingulum contribute to memory impairment among older adults with obstructive sleep apnea in the memory clinic"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6087-3565","authenticated-orcid":false,"given":"Aaron","family":"Lam","sequence":"first","affiliation":[{"name":"The Healthy Brain Ageing Program, Brain and Mind Centre The University of Sydney  Camperdown New South Wales Australia"},{"name":"School of Psychology Faculty of Science The University of Sydney  Camperdown New South Wales Australia"},{"name":"The Woolcock Institute of Medical Research  Macquarie Park New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannes","family":"Almgren","sequence":"additional","affiliation":[{"name":"The Healthy Brain Ageing Program, Brain and Mind Centre The University of Sydney  Camperdown New South Wales Australia"},{"name":"School of Biomedical Engineering, Faculty of Engineering The University of Sydney  Camperdown New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jake","family":"Palmer","sequence":"additional","affiliation":[{"name":"The Healthy Brain Ageing Program, Brain and Mind Centre The University of Sydney  Camperdown New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela L","family":"D'Rozario","sequence":"additional","affiliation":[{"name":"The Woolcock Institute of Medical Research  Macquarie Park New South Wales Australia"},{"name":"School of Psychological Sciences 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