{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T04:45:27Z","timestamp":1782535527858,"version":"3.54.5"},"reference-count":54,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T00:00:00Z","timestamp":1771977600000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100009408","name":"Fondation Brain Canada","doi-asserted-by":"publisher","award":["CFI Project 34874"],"award-info":[{"award-number":["CFI Project 34874"]}],"id":[{"id":"10.13039\/100009408","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009408","name":"Fondation Brain Canada","doi-asserted-by":"publisher","award":["33397"],"award-info":[{"award-number":["33397"]}],"id":[{"id":"10.13039\/100009408","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp; Dementia"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Enlargement of the choroidal\u2013ventricular system occurs in aging and Alzheimer's disease (AD), but emerging evidence links these abnormalities to amyloid beta (A\u03b2) aggregation. We tested this hypothesis by assessing associations between AD pathophysiology and choroidal\u2013ventricular system measures across the AD continuum.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>Ventricular volume, choroid\u2010plexus volume, and ventricular radioactivity after positron emission tomography (PET) tracer injections were analyzed in 385 Translational Biomarkers in Aging and Dementia (TRIAD) and 282 Alzheimer's Disease Neuroimaging Initiative (ADNI) participants using linear models and partial correlations. A composite score combining these measures was also tested against established AD biomarkers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>With advancing AD stages, ventricular and choroid\u2010plexus volumes increased while ventricular radioactivity declined. These measures were interrelated, and abnormalities appeared even in amyloid\u2010negative elderly. Across cohorts, they correlated with amyloid\u2010 and tau\u2010PET, cerebrospinal fluid (CSF) and plasma p\u2010tau isoforms, glial fibrillary acidic protein (GFAP), and cognition. Voxel\u2010wise analyses showed strong associations with cortical A\u03b2, mediating downstream tau effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Changes in the choroidal\u2013ventricular system are mutually correlated and carry an additive\u2010effect on cortical A\u03b2 load.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71205","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T23:48:47Z","timestamp":1773013727000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Choroidal\u2013ventricular system abnormalities are linked to amyloid\u2010\n                    <i>\u03b2<\/i>\n                    aggregation in Alzheimer's disease"],"prefix":"10.1002","volume":"22","author":[{"given":"Seyyed Ali","family":"Hosseini","sequence":"first","affiliation":[{"name":"Translational Neuroimaging Laboratory, McConnell Brain Imaging Centre Montreal Neurological Institute Montreal Neurological Institute McGill University  Montreal Quebec Canada"},{"name":"Department of Neurology and Neurosurgery McGill University  Montreal Quebec Canada"},{"name":"The McGill University Research Center for Studies in Aging Douglas Mental Health Institute  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Etienne","family":"Aumont","sequence":"additional","affiliation":[{"name":"Translational Neuroimaging Laboratory, McConnell Brain Imaging Centre Montreal Neurological Institute Montreal Neurological Institute McGill University  Montreal Quebec Canada"},{"name":"Department of Neurology and Neurosurgery McGill University  Montreal Quebec Canada"},{"name":"The McGill University Research Center for Studies in Aging Douglas Mental Health Institute  Montreal Quebec 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