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We examined whether LC integrity relates to whole\u2010brain integrity and how AD biomarkers may moderate this relationship.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      LC intensity and volume were estimated using automatic segmentation on neuromelanin\u2010sensitive magnetic resonance imaging acquired in\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a071 cognitively unimpaired elderly from the Age\u2010Well randomized controlled trial. We investigated the associations between LC integrity and whole\u2010brain gray matter volume (GMV) and glucose metabolism, as well as the interactions with amyloid positron emission tomography and plasma phosphorylated tau231, neurofilament light chain and glial fibrillary acidic protein.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>While only LC intensity was directly associated with GMV, both LC measures (intensity and volume) interacted positively with AD biomarkers to predict GMV and glucose metabolism.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Our results support concomitant LC and gray matter alterations in the context of aging and elevated AD biomarker levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CLINICAL TRIAL REGISTRATION<\/jats:title>\n                    <jats:p>Age\u2010Well randomized clinical trial of the Medit\u2010Ageing European Project. Trial registration number: EudraCT:2016\u2013002,441\u201336; IDRCB:2016\u2010A01767\u201344; ClinicalTrials.gov Identifier: NCT02977819.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71212","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T17:05:40Z","timestamp":1772989540000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Altered locus coeruleus links to atrophy and hypometabolism in individuals with high Alzheimer's disease biomarkers"],"prefix":"10.1002","volume":"22","author":[{"given":"Emilie","family":"Foyard","sequence":"first","affiliation":[{"name":"Normandie University, UNICAEN, INSERM, UA20, NEUROPRESAGE, Cyceron  Caen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Blanchard","sequence":"additional","affiliation":[{"name":"Normandie University, UNICAEN, INSERM, UA20, NEUROPRESAGE, Cyceron  Caen 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