{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T15:12:05Z","timestamp":1790694725228,"version":"4.1.0"},"reference-count":72,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T00:00:00Z","timestamp":1773273600000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>\n                      Apolipoprotein E (\n                      <jats:italic>APOE<\/jats:italic>\n                      ) alleles are well\u2010established genetic risk factors for Alzheimer's disease (AD), but their effects on AD biomarkers (amyloid beta [A\u03b2]42\/40, phosphorylated tau [p\u2010tau]181, neurofilament light chain [NfL], and glial fibrillary acidic protein [GFAP]) may vary across populations due to ancestry\u2010, age\u2010, and sex\u2010related differences. We hypothesized that these effects vary across Hispanic\/Latino background groups with distinct ancestral admixture.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>We analyzed \u03b52 and \u03b54 allele associations with AD biomarkers using survey\u2010weighted linear regression models, adjusting for demographic covariates. Secondary analyses examined genetic analysis group\u2010 and ancestry\u2010specific effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\u03b54 was associated with lower A\u03b242\/40 and higher p\u2010tau181and GFAP levels, but not with NfL, suggesting its role in A\u03b2 and tau deposition and neuroinflammation. \u03b54 associations were stronger in those with higher European and lower African ancestry.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>\n                      These findings expand on prior studies suggesting that genetic ancestry modifies\n                      <jats:italic>APOE<\/jats:italic>\n                      \u2010associated AD risk in Hispanic\/Latino populations and highlight the importance of capturing ancestry\u2010based heterogeneity in AD biomarker research.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71213","type":"journal-article","created":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T10:42:18Z","timestamp":1773312138000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["<i>APOE<\/i>\n                    and plasma AD biomarkers: The role of genetic ancestry in Hispanics\/Latinos"],"prefix":"10.1002","volume":"22","author":[{"given":"Caitlin","family":"Cheung","sequence":"first","affiliation":[{"name":"Department of Biostatistics Harvard T.H. 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