{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:28:01Z","timestamp":1786976881514,"version":"build-2736575974"},"reference-count":74,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T00:00:00Z","timestamp":1771891200000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R00AG065506"],"award-info":[{"award-number":["R00AG065506"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp; Dementia"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>The association of type 2 diabetes (T2D) treatment with Alzheimer's disease (AD) is unclear. We examined T2D treatment status in relation to amyloid beta (A\u03b2) burden and AD\u2010related downstream processes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      This cross\u2010sectional study included 546 cognitively unimpaired adults (mean age\u00a0=\u00a064.2\u00a0\u00b1\u00a03.2 years, 65% women), classified into normal glucose tolerance (NGT; hemoglobin A1c [HbA1c]\u00a0&lt;\u00a05.7%), prediabetes\/untreated T2D (HbA1c\u00a0\u2265\u00a05.7%), and treated T2D groups. Multiple regression analyses assessed group differences in A\u03b2 (\n                      <jats:sup>18<\/jats:sup>\n                      F\u2010florbetaben) and tau (\n                      <jats:sup>18<\/jats:sup>\n                      F\u2010MK\u20106240) positron emission tomography burden, magnetic resonance imaging\u2013based AD signature cortical thickness, white matter hyperintensity (WMH) volume, and memory performance.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Compared to the NGT group, prediabetes\/untreated T2D had greater anterior\/posterior cingulate and superior parietal cortex A\u03b2 burden, whereas treated T2D had lower cortical thickness and greater WMHs, independent of demographics and apolipoprotein E \u03b54 status. No group differences were found in tau or memory outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Prediabetes\/untreated T2D, but not treated T2D, was associated with early A\u03b2 deposition. Diabetes medications may mitigate brain A\u03b2 burden.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71214","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T19:33:38Z","timestamp":1772998418000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Association of type 2 diabetes treatment status with in vivo biomarkers of Alzheimer's disease"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0845-933X","authenticated-orcid":false,"given":"Muge","family":"Akinci","sequence":"first","affiliation":[{"name":"Department of Medicine, College of Physicians and Surgeons Columbia University Irving Medical Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Froogh","family":"Aziz","sequence":"additional","affiliation":[{"name":"Department of Medicine, College of Physicians and Surgeons Columbia University Irving Medical Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Guzman","sequence":"additional","affiliation":[{"name":"Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons Columbia University  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Cheung","sequence":"additional","affiliation":[{"name":"Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons Columbia University  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian X.","family":"Kong","sequence":"additional","affiliation":[{"name":"Department of Medicine, College of Physicians and Surgeons Columbia University Irving Medical Center  New York New York USA"},{"name":"Morris Stroud III Center for Study of Quality of Life in Health and Aging Columbia University  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Silver","sequence":"additional","affiliation":[{"name":"Department of Medicine, College of Physicians and Surgeons Columbia University Irving Medical Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Eimicke","sequence":"additional","affiliation":[{"name":"Department of Medicine, College of Physicians and Surgeons Columbia University Irving Medical Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanne A.","family":"Teresi","sequence":"additional","affiliation":[{"name":"Department of Medicine, College of Physicians and Surgeons Columbia University Irving Medical Center  New York New York USA"},{"name":"Morris Stroud III Center for Study of Quality of Life in Health and Aging Columbia University  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam M.","family":"Brickman","sequence":"additional","affiliation":[{"name":"Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons Columbia University  New York New York USA"},{"name":"Department of Neurology, Vagelos College of Physicians and Surgeons Columbia University  New York New York USA"},{"name":"Gertrude H. Sergievsky Center, Vagelos College of Physicians and Surgeons Columbia University  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Lao","sequence":"additional","affiliation":[{"name":"Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons Columbia University  New York New York USA"},{"name":"Department of Neurology, Vagelos College of Physicians and Surgeons Columbia University  New York New York USA"},{"name":"Gertrude H. 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