{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T22:38:07Z","timestamp":1792881487353,"version":"4.5.0"},"reference-count":47,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T00:00:00Z","timestamp":1772236800000},"content-version":"vor","delay-in-days":27,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp; Dementia"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Mild cognitive impairment (MCI) is a transitional stage to dementia, with cerebral small vessel disease (SVD) as a key contributor. Since retinal microvascular changes may mirror cerebral pathology, we investigated the associations between retinal microvasculature, neuroimaging, and plasma biomarkers in individuals with MCI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>61 MCI patients and 57 controls (CU) underwent retinal imaging, Neuroimaging (peak width of skeletonized diffusivity [PSMD], white matter hyperintensities [WMH]), plasma biomarker analysis, and cognitive assessment. Partial correlations and mediation analyses were adjusted for confounders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      MCI exhibited greater retinal tortuosity (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.05) and sparser vasculature (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001), correlating with higher PSMD, WMH volumes, and adverse plasma biomarkers (all\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.05). Mediation analysis revealed PSMD and WMH volumes partially mediated retinal\u2010cognitive associations (\n                      <jats:italic>p<\/jats:italic>\n                      for all mediation\u00a0&lt;\u00a00.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Retinal microvascular dysfunction in MCI reflects concurrent cerebral SVD and neurodegeneration, supporting its potential as a non\u2010invasive biomarker for early cognitive decline.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71216","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T18:05:35Z","timestamp":1772993135000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Retinal microvascular dysfunction in mild cognitive impairment: Associations with cerebral small vessel disease, plasma biomarkers, and cognitive decline"],"prefix":"10.1002","volume":"22","author":[{"given":"William Robert","family":"Kwapong","sequence":"first","affiliation":[{"name":"Department of Neurology Xuanwu Hospital, Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheli","family":"Chen","sequence":"additional","affiliation":[{"name":"Huzhou Third Municipal Hospital, the Affiliated Hospital of Wenzhou Medical Universiy the Affiliated Hospital of Huzhou University Huzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youjie","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology West China Hospital, Sichuan University Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqian","family":"Luan","sequence":"additional","affiliation":[{"name":"Department of Geriatrics The First Affiliated Hospital of Wenzhou Medical University Wenzhou 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