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To address this need, we explored relationships between AD\u2010associated variants and disease via their impact on gene expression and neuroanatomical phenotypes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>We mapped established AD genes to neuroimaging traits using the NeuroimaGene Atlas and predicted transcript\u2010driven neurological features of AD by comparing gene\u2010derived neuroimaging features with clinical neuroimaging data. Genetic covariance analyses were performed to characterize shared genetic architecture between AD endophenotypes and neuroimaging features, and to identify neuroimaging features associated with a family history of dementia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Our analyses implicate\n                      <jats:italic>PSMC3<\/jats:italic>\n                      as a contributor to AD pathophysiology and identify AD endophenotypes, including dementia family history, linked to frontal cortex thickness and volume, as well as changes in cerebrospinal fluid volume.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Our findings prioritize AD genes whose regulation is associated with vulnerable brain regions, offering a potential mechanistic framework for downstream functional validation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71217","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T11:20:01Z","timestamp":1772968801000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Neuroimaging PheWAS and molecular phenotyping implicate\n                    <i>PSMC3<\/i>\n                    in Alzheimer's disease"],"prefix":"10.1002","volume":"22","author":[{"given":"Xavier","family":"Bledsoe","sequence":"first","affiliation":[{"name":"Vanderbilt Genetics Institute Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6139-3168","authenticated-orcid":false,"given":"Ting\u2010Chen","family":"Wang","sequence":"additional","affiliation":[{"name":"Vanderbilt Genetics Institute Vanderbilt University Medical Center  Nashville Tennessee USA"},{"name":"Vanderbilt Memory and Alzheimer's Center Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiyang","family":"Wu","sequence":"additional","affiliation":[{"name":"Vanderbilt Memory and Alzheimer's Center Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derek","family":"Archer","sequence":"additional","affiliation":[{"name":"Vanderbilt Genetics Institute Vanderbilt University Medical Center  Nashville Tennessee USA"},{"name":"Vanderbilt Memory and Alzheimer's Center Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hung Hsin","family":"Chen","sequence":"additional","affiliation":[{"name":"Vanderbilt Genetics Institute Vanderbilt University Medical Center  Nashville Tennessee USA"},{"name":"Institute 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