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However, the genetic architecture of AD in non\u2010European populations remains underinvestigated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      We performed a genetic association study in East Asians (\n                      <jats:italic>N<\/jats:italic>\n                      \u00a0=\u00a08514) to validate known AD loci and identify new susceptibility loci.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      We identified\n                      <jats:italic>LILRB2\u2013LILRB5<\/jats:italic>\n                      as an AD susceptibility locus with ethnic\u2010specific effects between Europeans and East Asians. The lead variant, rs587709\u2010T, was associated with decreased AD risk and increased\n                      <jats:italic>LILRB5<\/jats:italic>\n                      expression in Europeans. Conversely, in East Asians, the same allele was associated with increased AD risk and increased\n                      <jats:italic>LILRB2<\/jats:italic>\n                      expression. Furthermore, genome\u2010wide analysis identified\n                      <jats:italic>TTC3<\/jats:italic>\n                      and\n                      <jats:italic>FAM135A<\/jats:italic>\n                      as candidate susceptibility loci for AD or cognition.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>\n                      The results establish\n                      <jats:italic>LILRB2\u2013LILRB5<\/jats:italic>\n                      as a cross\u2010ancestry AD\u2010associated locus with ethnic\u2010specific genetic mechanisms and reveal new susceptibility loci, extending the understanding of the genetic etiology of AD.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71219","type":"journal-article","created":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T08:26:10Z","timestamp":1771316770000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Ethnic\u2010specific effects of the\n                    <i>LILRB2\u2013LILRB5<\/i>\n                    locus and newly identified risk loci for Alzheimer's disease in the East Asian population"],"prefix":"10.1002","volume":"22","author":[{"given":"Han","family":"Cao","sequence":"first","affiliation":[{"name":"Division of Life Science State Key Laboratory of Nervous System Disorders Daniel and Mayce Yu Molecular Neuroscience Center The Hong Kong University of Science and Technology  Hong Kong Special Administrative Region China"},{"name":"InnoHK Hong Kong Center for Neurodegenerative Diseases  Hong Kong Special Administrative Region China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyu","family":"Zheng","sequence":"additional","affiliation":[{"name":"Division of Life Science State Key Laboratory of Nervous System Disorders Daniel and Mayce Yu Molecular Neuroscience Center The Hong Kong University of Science and Technology  Hong Kong Special Administrative Region China"},{"name":"InnoHK Hong Kong Center for Neurodegenerative Diseases  Hong Kong Special Administrative Region China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaopu","family":"Zhou","sequence":"additional","affiliation":[{"name":"Division of Life Science State Key Laboratory of Nervous System Disorders Daniel and Mayce Yu Molecular Neuroscience Center The Hong Kong University of Science and Technology  Hong Kong Special Administrative Region China"},{"name":"InnoHK Hong Kong Center for Neurodegenerative Diseases  Hong Kong Special Administrative Region China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masataka","family":"Kikuchi","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics Brain Research Institute Niigata University  Niigata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiu Yi","family":"Wong","sequence":"additional","affiliation":[{"name":"Division of Life Science State Key Laboratory of Nervous System Disorders Daniel and Mayce Yu Molecular Neuroscience Center The Hong Kong University of Science and Technology  Hong Kong Special Administrative Region China"},{"name":"InnoHK Hong Kong Center for Neurodegenerative Diseases  Hong Kong Special Administrative Region China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaine Y. L.","family":"Cheng","sequence":"additional","affiliation":[{"name":"Division of Life Science State Key Laboratory of Nervous System Disorders Daniel and Mayce Yu Molecular Neuroscience Center The Hong Kong University of Science and Technology  Hong Kong Special Administrative Region China"},{"name":"InnoHK Hong Kong Center for Neurodegenerative Diseases  Hong Kong Special Administrative Region China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bonnie W. Y.","family":"Wong","sequence":"additional","affiliation":[{"name":"Division of Life Science State Key Laboratory of Nervous System Disorders Daniel and Mayce Yu Molecular Neuroscience Center The Hong Kong University of Science and Technology  Hong Kong Special Administrative Region China"},{"name":"InnoHK Hong Kong Center for Neurodegenerative Diseases  Hong Kong Special Administrative Region China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronnie M. N.","family":"Lo","sequence":"additional","affiliation":[{"name":"Division of Life Science State Key Laboratory of Nervous System Disorders Daniel and Mayce Yu Molecular Neuroscience Center The Hong Kong University of Science and Technology  Hong Kong Special Administrative Region China"},{"name":"InnoHK Hong Kong Center for Neurodegenerative Diseases  Hong Kong Special Administrative Region China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Shoai","sequence":"additional","affiliation":[{"name":"Department of Neurodegenerative Disease Queen Square Institute of Neurology University College London  London UK"},{"name":"UK Dementia Research Institute University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joyce R.","family":"Chong","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Yong Loo Lin School of Medicine National University of Singapore  Singapore Singapore"},{"name":"Memory, Aging and Cognition Center National University Health System  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew L. 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